Results 191 to 200 of about 40,180 (256)

Haloperidol and Reduced Haloperidol in

Journal of Clinical Psychopharmacology, 1992
A total of 18 outpatients (17 male, 1 female) ranging in age from 36-66 years old were on a constant dosage of haloperidol in equally divided doses at 9:00 a.m. and 9:00 p.m. for at least 1 month. DSM-III-R diagnoses included schizophrenia (N = 9), schizoaffective disorder (N = 3), bipolar disorder (N = 4), organic mental disorder (N = 1), and ...
M W, Dysken, S B, Johnson, L, Holden, M, Kuskowski, J, Ofstehage, S, Skare, G, Vatassery   +6 more
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Quantification of Reduced Haloperidol and Haloperidol by Radioimmunoassay

Journal of Immunoassay, 1985
A radioimmunoassay for reduced haloperidol and haloperidol has been developed by using a simple derivatization-separation step prior to assay with an antibody cospecific for both compounds. The detection limit of the assay is less than 25 pg and shows no cross reactivity to other metabolites.
J L, Browning, C A, Harrington, C M, Davis   +2 more
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Determination of haloperidol and reduced haloperidol in the plasma and blood of patients on depot haloperidol

Psychopharmacology, 1992
We developed a sensitive HPLC assay to measure haloperidol (HA) and its metabolite, reduced haloperidol (RH), in plasma and whole blood. The conditions under which HA might be converted to RH during collection and analysis of blood were examined. Provided the blood was kept at 0 degrees C, erythrocyte ketone reductase activity was insignificant.
Eyles, Darryl W., Whiteford, Harvey A., Stedman, Terry J., Pond, Susan M.   +3 more
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Effects of smoking on haloperidol and reduced haloperidol plasma concentrations and haloperidol clearance

Psychopharmacology, 1986
Plasma concentrations of haloperidol and its reduced metabolite (reduced haloperidol) were investigated in cigarette smokers (N = 23) and nonsmokers (N = 27). Steady-state plasma concentrations were obtained 12 h post bedtime dose. Haloperidol and reduced haloperidol concentrations were determined by RIA.
M W, Jann, S R, Saklad, L, Ereshefsky, A L, Richards, C A, Harrington, C M, Davis   +5 more
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The Haloperidol Story

Annals of Clinical Psychiatry, 2005
Haloperidol was synthesized on the 11th of February 1958 at the Janssen Laboratories, in Belgium. Soon after its synthesis and animal studies, which suggested to Paul Janssen and his colleagues that this butyrophenone drug would be of great interest as its action was similar but much more powerful than that of chlorpromazine, haloperidol was ...
Bernard, Granger, Simona, Albu
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On the metabolism of haloperidol

Xenobiotica, 1993
1. p-Fluorobenzoyl-propionic acid, 4-(4-chlorophenyl)-4-hydroxy-piperidine, and reduced haloperidol were confirmed as metabolites of haloperidol. Their formation was catalysed by hepatic microsomes and was NADPH dependent. 2. The pyridinium metabolite of haloperidol (HP+) was identified.
J W, Gorrod, J, Fang
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Pharmacokinetics of Haloperidol

Clinical Pharmacokinetics, 1989
Haloperidol has been used extensively for the treatment of psychotic disorders, and it has been suggested that the monitoring of plasma haloperidol concentration is clinically useful. Different assay methodologies have been used in research and clinical practice to examine the relationship between response and plasma concentration of the drug. Chemical
J S, Froemming, Y W, Lam, M W, Jann, C M, Davis   +3 more
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Haloperidol Analgesia

Southern Medical Journal, 1981
Haloperidol was observed to be an effective analgesic, alone and in combination with opiates, in a patient with severe radiation fibrosis and necrosis. Previously, high doses of methadone and morphine, along with amitriptyline, had caused dangerous sedative side effects without providing adequate pain relief.
J L, Daw, S A, Cohen-Cole
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Reduced haloperidol/haloperidol ratios after oral haloperidol and decanoate administration in schizophrenics

Progress in Neuro-Psychopharmacology and Biological Psychiatry, 1993
1. Haloperidol and reduced haloperidol plasma concentrations were measured in thirteen stable schizophrenic patients that received both oral haloperidol and haloperidol decanoate. 2. Significant correlations between reduced haloperidol/haloperidol ratios from oral haloperidol and haloperidol decanoate occurred at week two and week 16, respectively.
W H, Chang, S K, Lin, D J, Juang, L C, Chen, C H, Yang, W H, Hu, C P, Chien, Y F, Lam, M W, Jann   +8 more
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Intersubject Variation in the Pharmacokinetics of Haloperidol and Reduced Haloperidol

Journal of Clinical Psychopharmacology, 1989
Single oral doses (5 mg) of haloperidol were administered to 36 healthy men (26 black, 10 white) of whom 28 (22 black, 6 white) completed the study. Plasma samples harvested over 96 hours were analyzed for haloperidol and reduced haloperidol by means of a new high performance liquid chromatographic method.
K K, Midha, B S, Chakraborty, D A, Ganes, E M, Hawes, J W, Hubbard, D L, Keegan, E D, Korchinski, G, McKay   +7 more
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