Results 91 to 100 of about 8,391 (212)
Molecular biology of viroid–host interactions and disease control strategies [PDF]
, 2014 Viroids are single-stranded, covalently closed, circular, highly structured noncoding RNAs that cause disease in several economically important crop plants.
Hammond, Rosemarie W. +1 more
core +1 more source
Unlocking the Potential of Chemically Modified Nucleic Acid Therapeutics
Advanced Therapeutics, Volume 7, Issue 11, November 2024.The advancements in nucleic acid therapeutics are highlighted, focusing on chemical modifications and bioconjugation techniques that enhance stability, binding affinity, and targeted delivery. Recent literature and clinical applications emphasize the role of backbone, ribose, base modifications, and bioconjugation strategies like N‐acetylgalactosamine (
Jingjing Gao +10 more
wiley +1 more source
Viroids: from genotype to phenotype just relying on RNA sequence and structural motifs
Frontiers in Microbiology, 2012 As a consequence of two unique physical properties, small size and circularity, viroid RNAs do not code for proteins and thus depend on RNA sequence/structural motifs for interacting with host proteins that mediate their invasion, replication, spread ...
Ricardo eFlores +4 more
doaj +1 more source
Ribozymes: the characteristics and properties of catalytic RNAs [PDF]
, 2017 Ribozymes, or catalytic RNAs, were discovered a little more than 15 years ago. They are found in the organelles of plants and lower eukaryotes, in amphibians, in prokaryotes, in bacteriophages, and in viroids and satellite viruses that infect plants.
Tanner, N. Kyle
core
An adaptive defect weighted sampling algorithm to design pseudoknotted RNA secondary structures
Frontiers in Genetics, 2016 Computational design of RNA sequences that fold into targeted secondary structures hasmany applications in biomedicine, nanotechnology and synthetic biology.
Kasra Zandi +3 more
doaj +1 more source
eLife, 2016 The nonenzymatic replication of RNA is a potential transitional stage between the prebiotic chemistry of nucleotide synthesis and the canonical RNA world in which RNA enzymes (ribozymes) catalyze replication of the RNA genomes of primordial cells ...
Noam Prywes +3 more
doaj +1 more source
Hammerhead ribozyme-based U-insertion and deletion RNA editing assays for multiplexing in HTS applications. [PDF]
RNA, 2023 Rostamighadi M +4 more
europepmc +1 more source
Enhanced RNA knockdown efficiency with engineered fusion guide RNAs that function with both CRISPR-CasRx and hammerhead ribozyme. [PDF]
Genome Biol, 2023 Zhan Y, Cao C, Li A, Mei H, Liu Y.
europepmc +1 more source
Giant reverse transcriptase-encoding transposable elements at telomeres [PDF]
, 2017 Author Posting. © The Author(s), 2017. This is the author's version of the work. It is posted here by permission of Oxford University Press for personal use, not for redistribution.
Arkhipova, Irina R. +2 more
core +1 more source
, 2009 Ribozimi su katalitičke molekule koje moraju biti savijene u visoko uređene tercijarne strukture, kao što to proteini rade da bi obavljali svoje funkcije. Glavni cilj je dovesti nukleofil i izrezujući fosfat u blizinu i aktivirati ih.
Zoko, Nikolina
core +2 more sources