Results 121 to 130 of about 6,878 (169)
Design and testing of Hepatitis Delta Ribozymes for suppression of Chikungunya virus infection in cell cultures. [PDF]
Med Res ArchFraser ME +4 more
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A polymerase ribozyme that can synthesize both itself and its complementary strand
Gianni E +6 more
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Comparison of the Structures and Mechanisms of the Pistol and Hammerhead Ribozymes [PDF]
Journal of the American Chemical Society, 2019 Comparison of the secondary and three-dimensional structures of the hammerhead and pistol ribozymes reveals many close similarities, so in this work we have asked if they are mechanistically identical.
Nan-sheng Li +2 more
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Biopolymers, 1999 The hammerhead ribozyme is an intriguing RNA molecule with the ability to serve as a catalyst to cleave sequence-specifically RNA molecules in an intermolecular reaction. Preferentially Mg(2+) is required for optimal activity by inducing the catalytically competent conformation and by possibly acting as an acid-base catalyst.
Fritz Eckstein, Birgit Bramlage
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Biochemical Society Transactions, 2002
The hammerhead ribozyme is a small RNA motif consisting of three helices that intersect at a conserved core. When correctly folded, the hammerhead ribozyme stimulates nearly complete cleavage of the phosphodiester chain at a defined internal site to give 2′,3′-cyclic and 5′-hydroxy termini. The cleavage rate is approx.
Olke C. Uhlenbeck, Kenneth F. Blount
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The hammerhead ribozyme is a small RNA motif consisting of three helices that intersect at a conserved core. When correctly folded, the hammerhead ribozyme stimulates nearly complete cleavage of the phosphodiester chain at a defined internal site to give 2′,3′-cyclic and 5′-hydroxy termini. The cleavage rate is approx.
Olke C. Uhlenbeck, Kenneth F. Blount
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Cytotoxic Hammerhead Ribozymes
Antisense and Nucleic Acid Drug Development, 1999Small catalytic RNA molecules of the hammerhead ribozyme type were found to have cytotoxic effects unrelated to their intended activity. An expression library of ribozyme sequence variants was constructed in a recA-deficient strain of Escherichia coli such that individual library members differed in regions designed to form base pairs with human ...
Xilin Zhao +10 more
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Hammerhead ribozyme engineering
Current Opinion in Structural Biology, 1996Of all the catalytic RNAs the hammerhead ribozyme is the most chemically modified and structurally studied. Such studies have resulted in improvements in the nuclease resistance of ribozymes, reductions in their size, and improvements in their catalytic efficiency.
Leonid Beigelman +2 more
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An Allosteric Hammerhead Ribozyme
Nature Biotechnology, 1995We have constructed an RNA molecule containing a hammerhead ribozyme that is under allosteric control. In the inactive state, the RNA enzyme is unable to cleave a suitable substrate. The formation of the active state of the ribozyme is triggered by a specific interaction with a DNA oligonucleotide effector that is complementary to a single-stranded ...
Helena Porta, Paul M. Lizardi
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The Hammerhead Ribozyme Structure Brought in Line [PDF]
ChemBioChem, 2006 AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Christian Hammann, Rita Przybilski
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Allosteric Hammerhead Ribozyme TRAPs
Biochemistry, 2002A new mode of allosteric regulation of nucleic acid enzymes is described and shown to operate effectively with hammerhead ribozymes. In the "TRAP" design (for targeted ribozyme-attenuated probe), a 3' terminal "attenuator" anneals to conserved bases in the catalytic core to form the "off" state of the ribozyme.
Nicole D. S. Ozerova +2 more
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