Results 141 to 150 of about 19,908 (281)

Can hammerhead ribozymes be efficient tools to inactivate gene function? [PDF]

, 1994
Édouard Bertrand, Raymond Pictet, Thierry Grange   +2 more
openalex   +1 more source

Inhibition of human immunodeficiency virus-1 entry using vectors expressing a multimeric hammerhead ribozyme targeting the CCR5 mRNA.

Journal of General Virology, 2008
Rz1-7 is a multimeric hammerhead ribozyme targeting seven unique sites within the human CCR5 mRNA that is active in vitro. Mouse stem cell virus-based MGIN and human immunodeficiency virus (HIV)-1-based HEG1 vectors were used to express Rz1-7 in a human ...
Reza Nazari, Xuezhong Ma, S. Joshi
semanticscholar   +1 more source

p150 ADAR1 isoform involved in maintenance of HeLa cell proliferation

BMC Cancer, 2006
Background RNA-specific adenosine deaminase ADAR1 is ubiquitously expressed in a variety of mammalian cells and tissues. Although its physiological importance in non-nervous tissues has been confirmed by analysis of null mutation phenotypes, few ...
Wu Yumei, Hou Zheng, Wang Haifang, Ma Xue, Luo Xiaoxing   +4 more
doaj   +1 more source

A hammerhead ribozyme allows synthesis of a new form of theTetrahymenaribozyme homogeneous in length with a 3' end blocked for transesterification [PDF]

, 1991
Cheryl A. Grosshans, Thomas R. Cech
openalex   +1 more source

The Suppression of MUC1 Expression in Cultured Cholangiocarcinoma Cells Using Antisense MUC1 Ribozyme Strategy

Siriraj Medical Journal, 2002
Ribozyme strategy has been employed to suppress the expression of target genes with a better efficacy than that of a regular antisense RNA strategy due to its favorable stoichiometry of the hybridization.
Valla Wamanutajinda, Adisak Wongkajornsilp, Yudhtana Sattawatthamrong, Sukit Huabprasert   +3 more
doaj  

RNAiFold2T: Constraint Programming design of thermo-IRES switches

, 2016
Motivation: RNA thermometers (RNATs) are cis-regulatory ele- ments that change secondary structure upon temperature shift. Often involved in the regulation of heat shock, cold shock and virulence genes, RNATs constitute an interesting potential resource ...
Clote, Peter, Dotu, Ivan, Fernandez-Chamorro, Javier, Garcia-Martin, Juan Antonio, Lozano, Gloria, Martinez-Salas, Encarnacion, Ramajo, Jorge   +6 more
core   +2 more sources

Cellular delivery of hammerhead ribozymes [PDF]

, 1997
Hammerhead ribozymes are potent RNA molecules which have the potential to specifically inhibit gene expression by catalysing the trans-cleavage of mRNAs. However, they are unstable in biological fluids and cellular delivery poses a problem. Site-specific chemical modification of hammerhead ribozymes was evaluated as a means of enhancing biological ...
openaire   +1 more source

Internal initiation of reverse transcription in a Penelope-like retrotransposon

Mobile DNA
Eukaryotic retroelements are generally divided into two classes: long terminal repeat (LTR) retrotransposons and non-LTR retrotransposons. A third class of eukaryotic retroelement, the Penelope-like elements (PLEs), has been well-characterized ...
Chris J. Frangieh, Max E. Wilkinson, Daniel Strebinger, Jonathan Strecker, Michelle L. Walsh, Guilhem Faure, Irina A. Yushenova, Rhiannon K. Macrae, Irina R. Arkhipova, Feng Zhang   +9 more
doaj   +1 more source

Magnesium-mediated Conversion of an Inactive Form of a Hammerhead Ribozyme to an Active Complex with Its Substrate [PDF]

, 1996
Masaya Orita, Ravi Vinayak, Alex Andrus, Masaki Warashina, Atsushi Chiba, Hidetoshi Kaniwa, Fumiko Nishikawa, Satoshi Nishikawa, Kazunari Taira   +8 more
openalex   +1 more source

Ribozymes: the characteristics and properties of catalytic RNAs [PDF]

, 2017
Ribozymes, or catalytic RNAs, were discovered a little more than 15 years ago. They are found in the organelles of plants and lower eukaryotes, in amphibians, in prokaryotes, in bacteriophages, and in viroids and satellite viruses that infect plants.
Tanner, N. Kyle
core