Results 11 to 20 of about 16,494 (236)
A hammerhead ribozyme selects mechanically stable conformations for catalysis against viral RNA [PDF]
Communications BiologyRibozymes, widely found in prokaryotes and eukaryotes, target nucleic acids and can be engineered as biotechnical tools or for gene regulation or immune therapy. Among them, hammerhead is the smallest and best characterized ribozyme.
Man Lu +11 more
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Molecular Therapy: Nucleic Acids, 2013 Target substrate-specific hammerhead ribozyme cleaves the specific mRNA efficiently and results in the inhibition of gene expression. In humans, overproduction of apolipoprotein B (apoB) is positively associated with premature coronary artery diseases ...
Hersharan Nischal +6 more
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Intronic hammerhead ribozymes in mRNA biogenesis [PDF]
bchm, 2012 Abstract Small self-cleaving ribozymes are a group of natural RNAs that are capable of catalyzing their own and sequence-specific endonucleolytic cleavage. One of the most studied members is the hammerhead ribozyme (HHR), a catalytic RNA originally discovered in subviral plant pathogens but recently shown to reside in a myriad of genomes
Inmaculada García‐Robles +2 more
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Eukaryotic penelope-like retroelements encode hammerhead ribozyme motifs. [PDF]
Mol Biol Evol, 2014 Small self-cleaving RNAs, such as the paradigmatic Hammerhead ribozyme (HHR), have been recently found widespread in DNA genomes across all kingdoms of life.
Cervera A, De la Peña M.
europepmc +2 more sources
Effective suppression of Dengue fever virus in mosquito cell cultures using retroviral transduction of hammerhead ribozymes targeting the viral genome [PDF]
Virology Journal, 2009 Outbreaks of Dengue impose a heavy economic burden on developing countries in terms of vector control and human morbidity. Effective vaccines against all four serotypes of Dengue are in development, but population replacement with transgenic vectors ...
Mohammed Ahmed +10 more
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The unforeseeable hammerhead ribozyme [PDF]
F1000 Biology Reports, 2009 Despite its small size, the complex behavior of the hammerhead ribozyme keeps surprising us, even more than 20 years after its discovery. Here, we summarize recent developments in the field, in particular the discovery of the first split hammerhead ...
C. Hammann, E. Westhof
semanticscholar +3 more sources
Discovery of novel hammerhead, twister, and DVRz-associated circular RNAs in Vitaceae, Solanaceae, and Rosaceae [PDF]
mSystemsViroids and viroid-like exogenous circular RNAs (ex-circRNAs) are small infectious RNA agents capable of autonomous replication within host cells, independent of any helper virus.
Ali Raza +3 more
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Capturing hammerhead ribozyme structures in action by modulating general base catalysis. [PDF]
PLoS Biology, 2008 We have obtained precatalytic (enzyme-substrate complex) and postcatalytic (enzyme-product complex) crystal structures of an active full-length hammerhead RNA that cleaves in the crystal.
Young-In Chi +5 more
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BMC Evolutionary Biology, 2010 Background The great variety in sequence, length, complexity, and abundance of satellite DNA has made it difficult to ascribe any function to this genome component.
Venanzetti Federica +3 more
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Design and Preparation of a Multimeric Self-Cleaving Hammerhead Ribozyme
BioTechniques, 1997 The activity of a ribozyme can be impaired by additional sequences at the 5′ and 3′ termini of the catalytic sequence. To approach this problem, a system was designed that minimizes sequences upstream and downstream from active regions of a hammerhead ...
Juan Ruiz +3 more
doaj +2 more sources