Results 221 to 230 of about 19,908 (281)

Identification of Hammerhead-variant ribozyme sequences in SARS-CoV-2. [PDF]

Nucleic Acids Res
Liu G, Jiang H, Chen D, Murchie AIH.
europepmc   +1 more source

Emergent ribozyme behaviors in oxychlorine brines indicate a unique niche for molecular evolution on Mars. [PDF]

Nat Commun
Hoog TG, Pawlak MR, Gaut NJ, Baxter GC, Bethel TA, Adamala KP, Engelhart AE.   +6 more
europepmc   +1 more source

RNA life on the edge of catastrophe. [PDF]

Proc Natl Acad Sci U S A
Chen IA.
europepmc   +1 more source

Weak effects of prebiotically plausible peptides on self-triphosphorylation ribozyme function. [PDF]

RSC Chem Biol
Arriola JT, Poordian S, Valdivia EM, Le T, Leman LJ, Schellinger JG, Müller UF.   +6 more
europepmc   +1 more source

A polymerase ribozyme that can synthesize both itself and its complementary strand

Gianni E, Kwok SLY, Wan CJK, Goeij K, Clifton BE, Attwater J, Holliger P.   +6 more
europepmc   +1 more source

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Probing General Base Catalysis in the Hammerhead Ribozyme

Journal of the American Chemical Society, 2008
Recent structural and computational studies have shed new light on the catalytic mechanism and active site structure of the RNA cleaving hammerhead ribozyme. Consequently, specific ribozyme functional groups have been hypothesized to be directly involved
Jason M. Thomas, D. Perrin
exaly   +2 more sources

The hammerhead ribozyme [PDF]

Biopolymers, 1999
The hammerhead ribozyme is an intriguing RNA molecule with the ability to serve as a catalyst to cleave sequence-specifically RNA molecules in an intermolecular reaction. Preferentially Mg(2+) is required for optimal activity by inducing the catalytically competent conformation and by possibly acting as an acid-base catalyst.
Fritz Eckstein, Birgit Bramlage
openaire   +2 more sources

Characterization of hammerhead ribozyme reactions.

Methods in molecular biology, 2012
Hammerhead ribozymes are small catalytic RNA motifs ubiquitously present in a large variety of genomes. The reactions catalyzed by these motifs are both their self-scission and the reverse ligation reaction. Here, we describe methods for the generation of DNA templates for the subsequent in vitro transcription of hammerhead ribozymes.
A. Kalweit, R. Przybilski, Carsten Seehafer, M. de la Peña, C. Hammann   +4 more
semanticscholar   +4 more sources

The hammerhead ribozyme

Biochemical Society Transactions, 2002
The hammerhead ribozyme is a small RNA motif consisting of three helices that intersect at a conserved core. When correctly folded, the hammerhead ribozyme stimulates nearly complete cleavage of the phosphodiester chain at a defined internal site to give 2′,3′-cyclic and 5′-hydroxy termini. The cleavage rate is approx.
Olke C. Uhlenbeck, Kenneth F. Blount
openaire   +3 more sources