Comparison of the Structures and Mechanisms of the Pistol and Hammerhead Ribozymes [PDF]
Journal of the American Chemical Society, 2019 Comparison of the secondary and three-dimensional structures of the hammerhead and pistol ribozymes reveals many close similarities, so in this work we have asked if they are mechanistically identical.
Nan-sheng Li +2 more
exaly +5 more sources
Effects of lipid membranes on RNA catalytic activity and stability. [PDF]
Biol CellThis study explores how lipid membranes influence the activity and stability of natural ribozymes. We found that lipid membranes can both decrease and enhance ribozyme activity. We also observed that lipid membranes promote RNA degradation, depending on lipid composition and membrane fluidity.
Czerniak T, Saenz JP.
europepmc +2 more sources
Programming anti-ribozymes to sense trigger RNAs for modulating gene expression in mammalian cells [PDF]
Synthetic and Systems BiotechnologySynthetic RNA-based switches provide distinctive merits in modulating gene expression. Simple and flexible RNA-based switches are crucial for advancing the field of gene regulation, paving the way for innovative tools that can sense and manipulate ...
Wenhui Zhang +5 more
doaj +2 more sources
Highly motif- and organism-dependent effects of naturally occurring hammerhead ribozyme sequences on gene expression. [PDF]
RNA Biol, 2018 Wurmthaler LA, Klauser B, Hartig JS.
europepmc +2 more sources
A Discovery with Potential to Revitalize Hammerhead Ribozyme Therapeutics for Treatment of Inherited Retinal Degenerations. [PDF]
Adv Exp Med Biol, 2019 Trujillo AJ +4 more
europepmc +2 more sources
Numerous small hammerhead ribozyme variants associated with Penelope-like retrotransposons cleave RNA as dimers. [PDF]
RNA Biol, 2017 Lünse CE +3 more
europepmc +2 more sources
Enhanced product stability in the hammerhead ribozyme. [PDF]
Biochemistry, 2010 The rate of dissociation of P1, the 5' product of hammerhead cleavage, is 100-300-fold slower in full-length hammerheads than in hammerheads that either lack or have disrupting mutations in the loop-loop tertiary interaction. The added stability requires
Shepotinovskaya I, Uhlenbeck OC.
europepmc +2 more sources
The hammerhead ribozyme: structure, catalysis, and gene regulation. [PDF]
Prog Mol Biol Transl Sci, 2013 Scott WG, Horan LH, Martick M.
europepmc +2 more sources
Active-site monovalent cations revealed in a 1.55-Å-resolution hammerhead ribozyme structure. [PDF]
J Mol Biol, 2013 Anderson M +3 more
europepmc +2 more sources
Existence of efficient divalent metal ion-catalyzed and inefficient divalent metal ion-independent channels in reactions catalyzed by a hammerhead ribozyme [PDF]
Nucleic Acids Research, 2002 Jiemin Zhou
exaly +2 more sources