Results 21 to 30 of about 16,494 (236)

RNA-peptide interactions tune the ribozyme activity within coacervate microdroplet dispersions [PDF]

Nature Communications
Membrane-free complex coacervate microdroplets are compelling models for primitive compartmentalisation with the ability to form from biological molecules.
Basusree Ghosh, Patrick M. McCall, Kristian Kyle Le Vay, Archishman Ghosh, Lars Hubatsch, David T. Gonzales, Jan Brugués, Hannes Mutschler, T-Y. Dora Tang   +8 more
doaj   +2 more sources

Aptazyme-mediated gene regulation in Strongyloides stercoralis for functional studies of insulin receptor isoform specificity. [PDF]

PLoS Pathogens
Hammerhead ribozymes have found extensive applications in gene expression regulation across diverse biological systems including Escherichia coli, yeast, plants, and mammalian cells. However, their implementation in parasitic nematodes remains unexplored.
Biying Zhang, Taoxun Zhou, Runxin Zhu, Peixi Qin, Juncheng Li, Chunqun Wang, Hui Liu, Min Hu   +7 more
doaj   +2 more sources

Programming anti-ribozymes to sense trigger RNAs for modulating gene expression in mammalian cells [PDF]

Synthetic and Systems Biotechnology
Synthetic RNA-based switches provide distinctive merits in modulating gene expression. Simple and flexible RNA-based switches are crucial for advancing the field of gene regulation, paving the way for innovative tools that can sense and manipulate ...
Wenhui Zhang, Shi Zhao, Mengyuan Wang, Chunbo Lou, Yanhui Xiang, Qiong Wu   +5 more
doaj   +2 more sources

A Discovery with Potential to Revitalize Hammerhead Ribozyme Therapeutics for Treatment of Inherited Retinal Degenerations. [PDF]

Adv Exp Med Biol, 2019
Trujillo AJ, Myers JM, Fayazi ZS, Butler MC, Sullivan JM.   +4 more
europepmc   +2 more sources

Divalent Metal Ion Activation of a Guanine General Base in the Hammerhead Ribozyme: Insights from Molecular Simulations. [PDF]

Biochemistry, 2017
Chen H, Giese TJ, Golden BL, York DM.
europepmc   +2 more sources

Numerous small hammerhead ribozyme variants associated with Penelope-like retrotransposons cleave RNA as dimers. [PDF]

RNA Biol, 2017
Lünse CE, Weinberg Z, Weinberg Z, Breaker RR.   +3 more
europepmc   +2 more sources

Highly motif- and organism-dependent effects of naturally occurring hammerhead ribozyme sequences on gene expression. [PDF]

RNA Biol, 2018
Wurmthaler LA, Klauser B, Hartig JS.
europepmc   +2 more sources

Small Molecule Recognition Triggers Secondary and Tertiary Interactions in DNA Folding and Hammerhead Ribozyme Catalysis. [PDF]

J Am Chem Soc, 2017
Mao J, DeSantis C, Bong D.
europepmc   +2 more sources

Two Active Site Divalent Ions in the Crystal Structure of the Hammerhead Ribozyme Bound to a Transition State Analogue. [PDF]

Biochemistry, 2016
Mir A, Golden BL.
europepmc   +2 more sources

Two Divalent Metal Ions and Conformational Changes Play Roles in the Hammerhead Ribozyme Cleavage Reaction. [PDF]

Biochemistry, 2015
Mir A, Chen J, Robinson K, Lendy E, Goodman J, Neau D, Golden BL.   +6 more
europepmc   +2 more sources