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Theoretical Studies of the Self Cleavage Pistol Ribozyme Mechanism [PDF]
, 2021 Ribozymes are huge complex biological catalysts composed of a combination of RNA and proteins. Nevertheless, there is a reduced number of small ribozymes, the self-cleavage ribozymes, that are formed just by RNA and, apparently, they existed in cells of ...
Bertran, Joan +4 more
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Hammerhead ribozymes going viral [PDF]
Genome Biology, 2016 An association between hammerhead ribozymes and non-autonomous, long terminal repeat retrotransposons is uncovered in plants, shedding light on the biological function of genomically encoded ribozymes.
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Ribozymes: The hammerhead swings into action [PDF]
Current Biology, 1998 A new crystal structure of a modified hammerhead ribozyme reveals an intermediate conformation that may explain discrepancies between previous structures and the required orientation of the labile bond in the ribozyme's active site.
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The RNA Newton Polytope and Learnability of Energy Parameters [PDF]
, 2013 Despite nearly two scores of research on RNA secondary structure and RNA-RNA interaction prediction, the accuracy of the state-of-the-art algorithms are still far from satisfactory.
Chitsaz, Hamidreza +1 more
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Complete RNA inverse folding: computational design of functional hammerhead ribozymes
, 2014 Nanotechnology and synthetic biology currently constitute one of the most innovative, interdisciplinary fields of research, poised to radically transform society in the 21st century. This paper concerns the synthetic design of ribonucleic acid molecules,
Clote, Peter +5 more
core +1 more source
The roles of cosolutes on the hammerhead ribozyme activity [PDF]
Nucleic Acids Symposium Series, 2006 The hammerhead ribozyme is often used for gene regulations in a cell. One of the major differences between in vitro and in cell conditions is the molecular crowding. However, the influence of crowding conditions on the ribozyme activity is still unclear. Here, we investigated the activity of the hammerhead ribozyme under molecular crowding condition by
Hisae Karimata +2 more
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Distribution of hammerhead and hammerhead-like RNA motifs through the GenBank [PDF]
, 2000 Hammerhead ribozymes previously were found in satellite RNAs from plant viroids and in repetitive DNA from certain species of newts and schistosomes. To determine if this catalytic RNA motif has a wider distribution, we decided to scrutinize the GenBank ...
Bourdeau, V. +4 more
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Angewandte Chemie, Volume 137, Issue 8, February 17, 2025.Synthetic biomolecular condensates are appealing candidates to replicate key features and functions of intracellular membrane‐less organelles. Their dynamic phase‐separation control provides crucial insights into the regulation of fundamental cell processes.
Siyu Song +6 more
wiley +2 more sources
Steric Interference Modification of the Hammerhead Ribozyme [PDF]
Chemistry & Biology, 2002 Although the structure of the hammerhead ribozyme is well characterized, many questions remain about its catalytic mechanism. Extensive evidence suggests the necessity of a conformational change en route to the transition state. We report a steric interference modification approach for investigating this change.
Olke C. Uhlenbeck +4 more
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Explanation by a putative triester-like mechanism for the thio effects and Mn2+ rescues in reactions catalyzed by a hammerhead ribozyme [PDF]
, 1998 Divalent metal ion-dependent hammerhead ribozymes can cleave any RNA with a NUX triplet, wherein the N can be any residue and X can be C, U or A. In recent literature on the mechanism of action of hammerhead ribozymes, one important role of divalent ...
He, Qiu-Chen +3 more
core +1 more source