Structural and catalytic effects of an invariant purine substitution in the hammerhead ribozyme: implications for the mechanism of acid-base catalysis. [PDF]
Acta Crystallogr D Biol Crystallogr, 2014 Schultz EP, Vasquez EE, Scott WG.
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Integration of the hammerhead ribozyme into structured RNAs to measure ligand-binding events for riboswitch candidates and aptamers. [PDF]
Acta Biochim Biophys Sin (Shanghai)Zhang S +10 more
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Active-site monovalent cations revealed in a 1.55-Å-resolution hammerhead ribozyme structure. [PDF]
J Mol Biol, 2013 Anderson M +3 more
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Emergent Chemical Reactivity and Complexity of RNA Condensates. [PDF]
Angew Chem Int Ed EnglRNA condensates capable of substrate enrichment and catalysis modulate their environment. Could this start a catalytic selection loop or evolution? Abstract The RNA world hypothesis posits the existence of life‐like assemblies that consisted mostly of RNA.
Hauf S +4 more
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Trans-acting aptazyme for conditional gene knockdown in eukaryotic cells
Molecular Therapy: Nucleic Acids, 2023 Trans-acting hammerhead ribozyme inherits the advantages of being the smallest and best-characterized RNA-cleaving ribozyme, offering high modularity and the ability to cleave any desired sequence without the aid of any protein, as long as the target ...
Shan Zhou +11 more
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Molecular Therapy: Nucleic Acids, 2022 The naturally occurring structure and biological functions of RNA are correlated, which includes hammerhead ribozymes. We proposed new variants of hammerhead ribozymes targeting conserved structural motifs of segment 5 of influenza A virus (IAV) (+)RNA ...
Tomasz Czapik +3 more
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Hammerhead ribozyme kinetics [PDF]
RNA, 1998 The hammerhead ribozyme is a small RNA motif that self cleaves at a specific phosphodiester bond to produce 2′,3′ cyclic phosphate and 5′ hydroxyl termini (Hutchins et al., 1986; Forster & Symons, 1987a). The secondary structure of the hammerhead consists of three helices of arbitrary sequence and length (designated I, II, and III) that intersect at 15
T K, Stage-Zimmermann, O C, Uhlenbeck
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Hammerhead Ribozymes: Structural Insights, Catalytic Mechanisms, and Cutting-Edge Applications in Synthetic Biology. [PDF]
Int J Mol SciWang L, Liu Y, Xian X, Zhang H.
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Identification of hammerhead ribozymes in all domains of life reveals novel structural variations. [PDF]
PLoS Computational Biology, 2011 Hammerhead ribozymes are small self-cleaving RNAs that promote strand scission by internal phosphoester transfer. Comparative sequence analysis was used to identify numerous additional representatives of this ribozyme class than were previously known ...
Jonathan Perreault +6 more
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Life, 2022 The acquisition of functions via the elongation of nucleotides is an important factor in the development of the RNA world. In our previous study, we found that the introduction of complementary seven-membered kissing loops into inactive R3C ligase ...
Hiromi Mutsuro-Aoki, Koji Tamura
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