Results 41 to 50 of about 6,878 (169)

Targeting Triple‐Negative Breast Cancer: Resistance Mechanisms and Therapeutic Advancements

Cancer Medicine, Volume 14, Issue 9, May 2025.
ABSTRACT Background Triple‐negative breast cancer (TNBC) is one of the most heterogeneous and menacing forms of breast cancer, with no sustainable cure available in the current treatment landscape. Its lack of targets makes it highly unresponsive to various treatment modalities, which is why chemotherapy continues to be the primary form of treatment ...
Rachana Raman, Shristi Debata, Thirupugal Govindarajan, Praveen Kumar   +3 more
wiley   +1 more source

Simple and Efficient Transformation and Gene Editing of Marchantia polymorpha Spores

Current Protocols, Volume 5, Issue 5, May 2025.
Abstract Marchantia polymorpha (Marchantia) has become a model species for liverwort studies, owing to its rapid growth in vitro, ease of propagation, simple genetics, small genome, haploid‐dominant life cycle, and because it is amenable to genetic transformation.
Rebecca M. Yorker, Simon C. Deroles, Yanfei Zhou, Jennifer A. Tate, Kevin M. Davies, Nick W. Albert   +5 more
wiley   +1 more source

Classification of the nucleolytic ribozymes based upon catalytic mechanism [PDF]

, 2019
The nucleolytic ribozymes carry out site-specific RNA cleavage reactions by nucleophilic attack of the 2’-oxygen atom on the adjacent phosphorus with an acceleration of a million-fold or greater.
A Ferré-D'Amaré, A Forster, A Hampel, A Hampel, A Ke, A McLeod, A Perrotta, A Perrotta, A Ren, A Ren, A Roth, B Saville, B Saville, C Gaines, C Gaines, C Gaines, C Hutchins, D Eiler, D Klein, D Klein, F Jones, F Westheimer, G Slim, G Soukup, H van Tol, J Buzayan, J Cochrane, J Han, J Haseloff, J Murray, J Thomas, K Harris, K Young, L Hegg, L Kapinos, L Nguyen, L Zheng, M Canny, M Kuo, M Martick, M Oivanen, N Suslov, P Bevilacqua, P Rupert, R Breaker, S Das, S Kath-Schorr, S Koo, S Li, S Nakano, T Lee, T Wilson, T Wilson, T Wilson, T Wilson, W Winkler, Y Komatsu, Y Li, Y Liu, Y Liu, Z Weinberg, Z Weinberg   +61 more
core   +3 more sources

Phytohormones and emerging plant growth regulators in tailoring plant immunity against viral infections

Physiologia Plantarum, Volume 177, Issue 2, March/April 2025.
Abstract Viral infections are major contributors to crop yield loss and represent a significant threat to sustainable agriculture. Plants respond to virus attacks by activating sophisticated signalling cascades that initiate multiple defence mechanisms.
Kritika Shukla, Nikita, Altaf Ahmad, Md Salik Noorani, Ravi Gupta   +4 more
wiley   +1 more source

Site‐Selective Modification and Labeling of Native RNA

Chemistry – A European Journal, Volume 31, Issue 12, February 25, 2025.
The review highlights recent advancements in site‐selective modification and labeling of native RNA, an important area for the development of RNA therapeutics and fundamental RNA research. The applications, current challenges of existing methods and potential future direction of this field are also discussed.
Tuan‐Khoa Kha, Yiran Zhao, Ru‐Yi Zhu
wiley   +1 more source

Self-assembly Controls Self-cleavage of HHR from ASBVd (−): a Combined SANS and Modeling Study [PDF]

, 2016
International audienceIn the Avocado Sunblotch Viroid (ASBVd: 249-nt) from the Avsunviroidae family, a symmetric rolling-circle replication operates through an autocatalytic mechanism mediated by hammerhead ribozymes (HHR) embedded in both polarity ...
Leclerc, Fabrice, Martel, Anne, Maurel, Marie-Christine, Vergne, Jacques, Zaccai, Giuseppe, Řìhovà, Martina   +5 more
core   +3 more sources

Minimal Hammerhead Ribozymes with Uncompromised Catalytic Activity [PDF]

, 2015
© 2015 Elsevier Ltd. We report here that a single additional trans-Hoogsteen base-pairing interaction in the minimal hammerhead ribozyme transforms an RNA sequence possessing typically modest catalytic activity into one possessing greatly enhanced ...
Estell, W, O'Rourke, SM, Scott, WG
core   +2 more sources

Engineered allosteric ribozymes that respond to specific divalent metal ions [PDF]

, 2005
In vitro selection was used to isolate five classes of allosteric hammerhead ribozymes that are triggered by binding to certain divalent metal ion effectors. Each of these ribozyme classes are similarly activated by Mn(2+), Fe(2+), Co(2+), Ni(2+), Zn(2+)
Breaker, Ronald R., Liu, Yong, Zivarts, Maris   +2 more
core   +2 more sources

Targeted introduction of premature stop codon in plant mitochondrial mRNA by a designer pentatricopeptide repeat protein with C‐to‐U editing function

The Plant Journal, Volume 121, Issue 3, February 2025.
Significance Statement We present an example of an editing factor with a synthetic P‐type PPR tract capable of precise, targeted de novo RNA editing in plant mitochondria. This breakthrough enables sophisticated manipulation of gene expression in mitochondria, which have long been genetically inaccessible, and holds promise for applications not only in
Nikolay Manavski, Eslam Abdel‐Salam, Serena Schwenkert, Hans‐Henning Kunz, Andreas Brachmann, Dario Leister, Jörg Meurer   +6 more
wiley   +1 more source

Investigating and expanding the functionality of RNA catalysts: Studies of the hepatitis delta virus, the hammerhead, and the aminoacyl-tRNA synthetase-like ribozymes [PDF]

, 2016
Ribozymes, just like protein enzymes, catalyze diverse chemical reactions. The first goal of this dissertation is to understand the mechanism of ribozyme-mediated phosphodiester cleavage reaction.
Chen, Ji
core   +1 more source