Results 101 to 110 of about 160,302 (312)

DNA concentration in harvest affects retrovirus clearance capabilities of protein A chromatography

Biotechnology Progress, EarlyView.
Abstract Protein A chromatography is a key unit operation in biopharmaceutical purification, widely used to capture monoclonal antibodies (mAbs) from harvest cell culture fluid (HCCF). In addition to its primary function, protein A chromatography is also frequently tested for its ability to remove viruses. Although protein A specifically binds mAbs and
Lukas Döring, Sven Schubert, Nora Roos, Johannes Winderl, Annika Müller, Anna Ratermann, Matthias W. Kron, Jürgen Hubbuch   +7 more
wiley   +1 more source

Preclinical evaluation of a fully human, quadrivalent-hantavirus polyclonal antibody derived from a non-human source

mBio
Hantaviruses are rodent-borne viruses that cause severe disease in infected humans. In the New World, major hantaviruses include Andes virus (ANDV) and Sin Nombre virus (SNV) causing hantavirus pulmonary syndrome.
Rebecca L. Brocato, Hua Wu, Steven A. Kwilas, Lucia M. Principe, Matthew Josleyn, Joshua Shamblin, Padmanabh Chivukula, Christoph Bausch, Thomas Luke, Eddie J. Sullivan, Jay W. Hooper   +10 more
doaj   +1 more source

Amyloidosis in Hamsters with Leishmaniasis.

Experimental Biology and Medicine, 1946
SummaryForty-six days after successful inoculation of L. donovani into hamsters, there appeared edema associated with amyloidosis. There was marked anasarca at 60 and 77 days after infection with extensive deposition of amyloid in the glomeruli and the adrenal cortex. The hypoalbuminemia, which coincided with the edema and a proteinuria, is believed to
A. Gellhorn, H. B. van Dyke, W. J. Pyles, N. A. Tupikova   +3 more
openaire   +2 more sources

Beschermingsplan hamster 2005-2010 [PDF]

, 2005
Alterra-Concept van het beschermingsplan hamster 2005-2010. De hamster is in het meest westelijke deel van het Europese verspreidingsgebied bedreigd. De kennis die in de afgelopen periode is opgedaan van de hamster en de maatregelen die in het veld zijn ...
Haye, M.J.J., la, Jansman, H.A.H., la Haye, M.J.J.   +2 more
core  

Basic features and conservation of hamster lncRNAs.

, 2016
(a) The cumulative distributions of transcript lengths for the hamster lncRNAs (green), hamster protein-coding genes (blue), mouse lncRNAs (black), and mouse protein-coding genes (red).
Jianxin Lu (28270), Wei Li (7081), Ziyang Li (3097962), Haitao Luo (365511), Yi Zhao (14034), Chaoliang Xiong (3097965), Tingting Mao (1636900), Haiying Tian (3097959), Qian Chen (1235499), Quanzhen Li (3097953), Suo Mo (3097950), Mengqian Yu (3097956)   +11 more
core   +1 more source

Delineation of genomic deletion in cardiomyopathic hamster [PDF]

, 1999
Cardiomyopathic hamster is a representative animal model for autosomal recessive cardiomyopathy. We have previously shown that the transcript of δ-sarcoglycan is missing in the heart of cardiomyopathic hamster due to genomic deletion.
Makoto Abe, Aiji Sakamoto, Sakamoto, Aiji, Masaki, Tomoh, Abe, Makoto, Tomoh Masaki   +5 more
core   +1 more source

Regenerative perfusion bioreactor for biologics production with lower COGs

Biotechnology Progress, EarlyView.
Abstract Perfusion bioreactor systems enable intensified bioprocessing with high cell densities and volumetric productivities in monoclonal antibody (mAb) manufacturing. However, their widespread adoption remains constrained by the high consumption of chemically defined cell culture media.
Eric Wynne, Dohyun Park, Hourieh Ahi, Jaeweon Lee, Seongkyu Yoon, Jongyoon Han   +5 more
wiley   +1 more source

Pharmacological Activities of Fingerroot Extract and Its Phytoconstituents Against SARS-CoV-2 Infection in Golden Syrian Hamsters [Corrigendum]

Journal of Experimental Pharmacology, 2023
Kongratanapasert T, Kongsomros S, Arya N, et al. J Exp Pharmacol. 2023;15:13–26. Page 19, line two, the text “510.25 ± 329.37 and 2015.74 ± 708.53 μg/g” should read “510.25 ± 329.37 and 2015.74 ...
Kongratanapasert T, Kongsomros S, Arya N, Sutummaporn K, Wiriyarat W, Akkhawattanangkul Y, Boonyarattanasoonthorn T, Asavapanumas N, Kanjanasirirat P, Suksatu A, Sa-ngiamsuntorn K, Borwornpinyo S, Vivithanaporn P, Chutipongtanate S, Hongeng S, Ongphiphadhanakul B, Thitithanyanont A, Khemawoot P, Sritara P   +18 more
doaj  

Impact of single‐use bioreactor bag materials on Spodoptera frugiperda cell expansion for recombinant adeno‐associated virus manufacturing

Biotechnology Progress, EarlyView.
Abstract Recombinant adeno‐associated virus production for gene therapy applications commonly relies on the Spodoptera frugiperda 9 (Sf9) baculovirus infection platform. The process encompasses cell expansion from flasks through intermediate‐scale bioreactors to large‐scale production.
Min Tae Park, Seyed Pouria Motevalian
wiley   +1 more source

Peptide Marriages: Modular Assembly of Multi‐Agonist Therapeutics

Chemistry – A European Journal, EarlyView.
A modular polyethylene glycol (PEG) scaffold enables rapid assembly of dual peptide agonists using strain‐promoted azide–alkyne cycloaddition (SPAAC) and copper‐catalysed azide–alkyne cycloaddition (CuAAC). Glucagon‐like peptide‐1 (GLP‐1) and amylin agonists were combined with controlled valency, yielding low‐picomolar activity and receptor‐selective ...
Kristina A. Kostadinova, Jan L. Venne, Sona Krajcovicova, James Dodgson, Wouter F. J. Hogendorf, Thomas E. Nielsen, David Hymel, Hannah Bolt, Andie Collinson, Jason Day, Jefferson Revell, David R. Spring   +11 more
wiley   +1 more source