Results 121 to 130 of about 162,987 (311)
Neutralizing gut-derived lipopolysaccharide as a novel therapeutic strategy for severe leptospirosis
eLifeLeptospirosis is an emerging infectious disease caused by pathogenic Leptospira spp. Humans and some mammals can develop severe forms of leptospirosis accompanied by a dysregulated inflammatory response, which often results in death.
Xufeng Xie +5 more
doaj +1 more source
DNA concentration in harvest affects retrovirus clearance capabilities of protein A chromatography
Biotechnology Progress, EarlyView.Abstract Protein A chromatography is a key unit operation in biopharmaceutical purification, widely used to capture monoclonal antibodies (mAbs) from harvest cell culture fluid (HCCF). In addition to its primary function, protein A chromatography is also frequently tested for its ability to remove viruses. Although protein A specifically binds mAbs and
Lukas Döring +7 more
wiley +1 more source
Regenerative perfusion bioreactor for biologics production with lower COGs
Biotechnology Progress, EarlyView.Abstract Perfusion bioreactor systems enable intensified bioprocessing with high cell densities and volumetric productivities in monoclonal antibody (mAb) manufacturing. However, their widespread adoption remains constrained by the high consumption of chemically defined cell culture media.
Eric Wynne +5 more
wiley +1 more source
Biotechnology Progress, EarlyView.Abstract Recombinant adeno‐associated virus production for gene therapy applications commonly relies on the Spodoptera frugiperda 9 (Sf9) baculovirus infection platform. The process encompasses cell expansion from flasks through intermediate‐scale bioreactors to large‐scale production.
Min Tae Park, Seyed Pouria Motevalian
wiley +1 more source
Biotechnology Progress, EarlyView.Abstract Regeneron's bispecific technology, based on a fully human IgG antibody construct, consists of two distinct heavy chains and a common light chain co‐expressed in a single cell. The co‐expression of the two distinct heavy chains, one of which contains a dipeptide substitution that ablates Protein A binding, leads to the formation of three ...
Samantha Wadsworth +4 more
wiley +1 more source
Biotechnology Progress, EarlyView.Abstract Increasing protein therapeutics production by adopting intensified perfusion cultures places high demand on the mass transfer capabilities of single‐use bioreactors (SUB). Here, we compare these capabilities for four SUB designs against worst‐case O2 transfer requirements for supporting Chinese hamster ovary (CHO) perfusion cultures. Impact of
Anita B. Dabek +9 more
wiley +1 more source
Pengaruh Persilangan Hamster Campbell Normal Dengan Hamster Campbell Panda Dan Umur Induk Saat Dikawinkan Terhadap Penampilan Sifat – Sifat Produksi Anak [PDF]
, 2013 Hamster merupakan salah satu jenis hewan yang termasuk dalam jenis hewan pengerat. Pemeliharaan Hamster sendiri bertujuan untuk kesenangan atau hobby dan tidak bertujuan untuk produksi daging seperti sapi, kambing atau ayam.
M, WahyuKholliq
core
The Canadian Journal of Chemical Engineering, EarlyView.Abstract On the centennial of higher education in Chemical Engineering in Mexico, it is pertinent to revisit the key stages that have contributed to its consolidation as a vital discipline for the nation's scientific and technological advancement. Although the initial mission of chemical engineering education was primarily oriented toward the training ...
Agustín López Munguía +3 more
wiley +1 more source
Drug Testing and Analysis, EarlyView.A large‐scale evaluation of 164 commercially available anti‐human EPO antibodies was conducted to identify an alternative to clone AE7A5 anti‐EPO antibody used in doping control for the detection of erythropoiesis‐stimulating agents (ERAs) on Western blots.
Christian Reichel +3 more
wiley +1 more source