Results 131 to 140 of about 116,204 (266)

Hsp70 diversification and repurposing across the tree of life: Lessons from the evolutionary and mechanistic trajectory of the Hsp70–Hsp110 chaperone system

open access: yesThe FEBS Journal, EarlyView.
Evolutionary and mechanistic divergence in the Hsp70–Hsp110 chaperone system. Prokaryotic Hsp70s probably diversified into multiple orthologues that cooperated with co‐chaperones such as JDPs and NEF, forming increasingly complex proteostasis networks.
Pierre Goloubinoff   +2 more
wiley   +1 more source

Defining the role of αC helix interactions in the activation of the integrin αI domain

open access: yesThe FEBS Journal, EarlyView.
The α2I domain of the α2β1 integrin contains a distinctive αC helix and a conserved Arg288‐Glu318 ion pair that stabilizes the closed state of the domain. Disruption of this ion pair in the activated α2I variant unwinds the αC helix, which allows interaction with additional collagen‐binding sites increasing collagen binding.
Liisa Pösö   +7 more
wiley   +1 more source

MICROTUBULES IN HAMSTER PLATELETS [PDF]

open access: yesThe Journal of Cell Biology, 1965
G B, Haydon, D A, Taylor
openaire   +2 more sources

Innate Immune Activation Is a Strong Suppressor of CCL22 and Impedes Regulatory T Cell–Dendritic Cell Interaction

open access: yesImmunology, EarlyView.
During homeostasis, CCL22 is secreted by dendritic cells (DC), which mediate contacts between regulatory T cells (Treg) and DC to maintain immune balance. Activation of innate immunity via microbes or pattern recognition receptor (PRR) agonists induces the secretion of several soluble factors (e.g., type I and II interferons, IL‐10), which mediate ...
Ignazio Piseddu   +24 more
wiley   +1 more source

Differences in Feeding Management of Pet Rabbits by Owners and Hobby Breeders and Their Impact on Animals' Health: A Survey

open access: yesJournal of Animal Physiology and Animal Nutrition, EarlyView.
ABSTRACT Over the last decades, the population of pet rabbits in Europe has increased significantly, but to date studies into feeding management of these species have been mainly conducted in production animals. This study aimed to evaluate the feeding practices of both pet rabbit owners and hobby breeders in Germany and how these may affect animal ...
Federica Sportelli   +5 more
wiley   +1 more source

Periodontitis and Adverse Pregnancy Outcomes: Mechanistic Evidence

open access: yesJournal of Periodontal Research, EarlyView.
This narrative review aims to describe mechanisms linking periodontal diseases in pregnancy with adverse pregnancy outcomes. ABSTRACT Periodontal diseases, including both gingivitis and periodontitis, occur commonly among pregnant individuals. Both gingivitis and periodontitis are associated with adverse pregnancy outcomes (APOs) such as early ...
Gregory C. Valentine   +4 more
wiley   +1 more source

Home - About - Disclaimer - Privacy