Results 41 to 50 of about 612,123 (289)

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Tuberculosis risk-associated single nucleotide polymorphisms do not show association with leprosy in Chinese population

International Journal of Infectious Diseases, 2015
Objective: Leprosy and tuberculosis (TB) are chronic granulomatous infectious diseases. As well as pathogen and environmental factors, host genetic factors make a substantial contribution to susceptibility to both diseases.
Chuan Wang, Na Wang, Yongxiang Yu, Gongqi Yu, Zhenzhen Wang, Xi’an Fu, Hong Liu, Furen Zhang   +7 more
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Translation and Historiography: How an Interpreter Shaped Historical Records in Latter Han China [PDF]

, 2006
This article analyzes evidence of interpreting activities in first-century China between the Latter Han (25–220 AD) Chinese administration and non-Han Chinese minority tribes along the then Southwestern frontier (modern Yunnan and the west of Sichuan ...
Lung, Rachel
core   +1 more source

Spinocerebellar ataxia type 36 in the Han Chinese [PDF]

Neurology Genetics, 2016
To ascertain the genetic and clinical characteristics of the GGCCTG hexanucleotide repeat expansion in the nucleolar protein 56 gene (NOP56) in patients with spinocerebellar ataxia (SCA), sporadic ataxia, or amyotrophic lateral sclerosis (ALS) in Taiwan.We conducted clinical and molecular genetic studies of 109 probands with molecularly unassigned SCA ...
Lee, Yi-Chung, Tsai, Pei-Chien, Guo, Yuh-Cherng, Hsiao, Cheng-Tsung, Liu, Guan-Ting, Liao, Yi-Chu, Soong, Bing-Wen   +6 more
openaire   +2 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Comparison of lipidome profiles in human milk from Chinese Han and Korean ethnic groups based on high-throughput lipidomic techniques

Journal of Dairy Science
: The composition of milk lipids varies across different ethnic sources. The lipidome profiles of Chinese Han human milk (HHM) and Chinese Korean human milk (KHM) were investigated in this study.
Yuxue Sun, Jiafei Liu, Xiaowen Pi, Shilong Jiang, Jianjun Cheng, Mingruo Guo   +5 more
doaj   +1 more source

Genetic and Immune Predictors for Hypersensitivity Syndrome to Antiepileptic Drugs [PDF]

, 2011
Hypersensitivity syndrome reactions (HSR) to antiepileptic drugs (AED) are associated with severe clinical cutaneous adverse reactions (SCAR).Our aims are: to assess HSRs to AEDs using the in vitro lymphocyte toxicity assay (LTA) in patients who ...
Lawrence Cohen, Manuela G. Neuman, Paul A. Hwang, Radu M. Nanau   +3 more
core   +1 more source

BMP7 Gene involved in nonsyndromic orofacial clefts in Western han Chinese [PDF]

, 2015
Background: Nonsyndromic orofacial clefts (NSOCs) are the most common craniofacial birth defects with complex etiology in which multiple genes and environmental exposures are involved. Bone morphogenetic protein 7 (BMP7), as a member of the transforming
He, Sha, Jia, Zhonglin, Ma, Jian, Shi, Bing, Yu, Qiongqiong, Zeng, Ni, Zhang, Bihe   +6 more
core   +2 more sources

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source