Results 41 to 50 of about 81,923 (299)

A Rare Cause of Foot Pain: Os Trigonum Syndrome

, 2015
The os trigonum is an accessory bone which is usually asymptomatic and located behind the lateral bulge of the talus. During tough plantar flexion of the ankle, compression of the os trigonum between the posterior malleolus of the tibia and the tuber ...
Rabia Terzi, Gökhan Duygulu, Tülay Özer   +2 more
core   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Hand and wrist configurations in patients with Carpal Tunnel Syndrome [PDF]

, 2007
The association between hand and wrist configurations was investigated in this study. The hand and wrist dimensions of sixty patients with carpal tunnel syndrome and sixty healthy control subjects were measured using specific anatomical landmarks.
Gatt, Ray, Sciberras, Carmel, Galea, Laurence A.   +2 more
core  

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

False Positive Tumor Markers: Elevation in Patients with Breast Cancer on FAC-type Chemotherapy and Correlation with the Development of Hand-foot Syndrome

The International Journal of Biological Markers, 1996
Breast cancer patients on dose-intensive chemotherapy often have elevated tumor markers during the course of treatment. Our objective was to estimate the incidence of a “false positive” tumor marker screen and to determine whether hand-foot epithelial ...
L.B. Tyshler, G.M. Longton, G.K. Ellis, R.B. Livingston   +3 more
doaj   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Capecitabine Induced Hand-Foot Syndrome—A Case Report [PDF]

Rwanda Medical Journal, 2020
Hand and foot syndrome (HFS) is a dose-limiting dermatological toxic reaction of some chemotherapy agents like Capecitabine. Though not being life-threatening, the patient’s quality of life is compromised secondary to this syndrome. Early detection, dose
D. A. Ndoli, A. Manirakiza, F. Rubagumya
doaj  

Relationship Between Neurologic Symptoms and Signs and FMR1 Genotype in Premutation Carriers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Fragile X‐associated Tremor/Ataxia Syndrome (FXTAS) is the most severe late‐onset condition caused by a premutation in the FMR1 gene, characterized by expanded CGG triplet repeats of 55–200. Clinical presentations of FXTAS, including gait ataxia, kinetic tremor, cognitive decline, and rare Parkinsonism, are linked to ...
Flora Tassone, Freddy Chafota, Miguel E. Rentería, Randi J. Hagerman, Ellery Santos, Anna Atkinson, Nicholas G. Martin, Elsdon Storey, Danuta Z. Loesch   +8 more
wiley   +1 more source

Molecular factors involved in the development of diabetic foot syndrome [PDF]

, 2012
Diabetes is one of the major challenges of modern medicine, as it is considered a global epidemic of the XXI century. The disease often leads to the development of serious, health threatening complications.
Brun-Olszewska, Bożena, Olszewski, Paweł, Bruhn-Olszewska, Bożena, Węgrzyn, Alicja, Gabig-Cimińska, Magdalena, Korzon-Burakowska, Anna, Jakóbkiewicz-Banecka, Joanna   +6 more
core  

Lanolin-based dexpanthenol cream, topical hydrocortisone or observation in the prevention of capecitabine-induced hand-foot syndrome: a phase III trial

, 2022
Introduction: The use of capecitabine is associated with hand-foot syndrome (HFS). Since there is anecdotal evidence that lanolin-based creams and topical steroids are useful for the treatment of HFS, we conducted a three- arm phase III trial
Giuliano Santos Borges, Sergio Vicente Serrano, Carmen Silvia Passos Lima, Gustavo Colagiovanni Girotto, Daniela Dornelles Rosa, Artur Malzyner, Roberto Magnus Duarte Sales, Fernanda Maris Peria, Nilciza Maria de Carvalho Tavares Calux, Fabio André Franke, Ruffo Freitas, Leandro Brust, Cintia Sayuri Kurokawa La-Scala, Magda Conceição Barbosa Gomes   +13 more
core   +1 more source