Results 31 to 40 of about 6,214,658 (304)
NECSUS, 2015 The article presents a cultural historical rendition of the terms vintage and retro and how the revival of the recent past based on objects of modern culture is a characteristic feature of late 20th and 21st century culture.
Kristian Handberg
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Memoranda Book 041: Carey Hand Funeral Home records, March 7, 1927 to April 17, 1927 [PDF]
, 1927 Contains records and ledgers on services provided at the Carey Hand Funeral Home. Materials include memoranda regarding the death and burial of deceased individuals, registers of the death, burial and payment information, plots in the Greenwood and Palm ...
Carey Hand Funeral Home
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Plastic and Reconstructive Surgery, Global Open, 2023 Summary:. Silicone implant arthroplasty is an alternative surgical intervention for painful and deformed osteoarthritis of the distal interphalangeal (DIP) joints.
Satoshi Usami, MD +4 more
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FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Memoranda Book 049: Carey Hand Funeral Home records, June 1, 1928 to August 1, 1928 [PDF]
, 1928 Contains records and ledgers on services provided at the Carey Hand Funeral Home. Materials include memoranda regarding the death and burial of deceased individuals, registers of the death, burial and payment information, plots in the Greenwood and Palm ...
Carey Hand Funeral Home
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Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Testing and Proving, Hand-in-Hand
, 2010 The motivating ideal of my lifetime’s scientific research has been that of program correctness, achieved with the aid of mathematical proof. As suggested by Turing, Floyd, and others, the proofs would be based on the decoration of a program with assertions, that would be proved true if ever they were evaluated at the point where they were written in ...
openaire +3 more sources