Results 51 to 60 of about 5,277,467 (308)

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Knockdown of LMX1B Suppressed Cell Apoptosis and Inflammatory Response in IL-1β-Induced Human Osteoarthritis Chondrocytes through NF-κB and NLRP3 Signal Pathway

open access: yesMediators of Inflammation, 2022
Osteoarthritis (OA), a chronic degenerative joint disease, always occurred in the aging population. There is evidence suggests that chondrocytes’ survival, inflammation, and apoptosis play critical roles in OA pathogenesis.
Yiping Mu, Lining Wang, Ling Fu, Qi Li
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

Testing and Proving, Hand-in-Hand

open access: yes, 2010
The motivating ideal of my lifetime’s scientific research has been that of program correctness, achieved with the aid of mathematical proof. As suggested by Turing, Floyd, and others, the proofs would be based on the decoration of a program with assertions, that would be proved true if ever they were evaluated at the point where they were written in ...
openaire   +2 more sources

The human gut microbiome across the life course

open access: yesFEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero   +4 more
wiley   +1 more source

Raíces profundas: indias y británicas a la vez

open access: yesAsparkía, 2013
En un artículo publicado en 1993, el crítico Pico Iyer describió las estanterías de las librerías británicas como «tan ruidosas, políglotas y multicoloridas como las mismas calles británicas».
Felicity Hand
doaj  

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

open access: yesFEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Hands

open access: yesHCA Healthcare Journal of Medicine, 2021
Description "Hands" is inspired by my first encounter with a donor in the cadaver lab during my first year of medical school. This poem highlights the intimate relationship between the medical student and their "first patient" and captures the factors that helped me realize the grandeur of the dissecting experience.
openaire   +3 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Memoranda Book 111: Carey Hand Funeral Home records, March 23, 1937 to April 29, 1937

open access: yes, 1937
Contains records and ledgers on services provided at the Carey Hand Funeral Home. Materials include memoranda regarding the death and burial of deceased individuals, registers of the death, burial and payment information, plots in the Greenwood and Palm ...
Carey Hand Funeral Home
core  

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