Results 41 to 50 of about 3,735,029 (314)

Lesbian, Gay, Bisexual, Transgender, Asexual, Intersex Et Al. (LGBTQAI+) Health Access Disparities in Female-Identified Clients

Columbia Social Work Review, 2019
Though they recently received legal legitimacy, the LGBTQAI+ community faces discrimination through deeply entrenched heterosexist social systems, which amplify inequities for women and gender minorities. Social workers must advocate for expansive policy
Jennifer Hand
doaj  

Long-term patient-reported outcomes for open surgery of the triangular fibrocartilage complex

Bone & Joint Open, 2021
Aims: Studies on long-term patient-reported outcomes after open surgery for triangular fibrocartilage complex (TFCC) are scarce. Surgeons and patients would benefit from self-reported outcome data on pain, function, complications, and satisfaction after ...
Reinier Feitz, Sara Khoshnaw, Mark J. W. van der Oest, J. Sebastiaan Souer, Harm P. Slijper, Steven E. R. Hovius, Ruud W. Selles, On behalf of the Hand-Wrist Study Group   +7 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

G protein‐coupled receptors: walking hand‐in‐hand, talking hand‐in‐hand? [PDF]

British Journal of Pharmacology, 2011
Most cells express a panel of different G protein‐coupled receptors (GPCRs) allowing them to respond to at least a corresponding variety of extracellular ligands. In order to come to an integrative well‐balanced functional response these ligand–receptor pairs can often cross‐regulate each other.
Vischer, H.F., Watts, A.O., Nijmeijer, S., Leurs, R.   +3 more
openaire   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Inferior stabilization of cementless compared with cemented dual-mobility cups in elderly osteoarthrosis patients: a randomized controlled radiostereometry study on 60 patients with 2 years’ follow-up

Acta Orthopaedica, 2020
Background and purpose — Elderly patients may benefit from a dislocation low-risk dual-mobility (DM) articulation in total hip arthroplasty, but the best cup fixation method is unknown.
Steffan Tabori-Jensen, Sebastian Breddam Mosegaard, Torben B Hansen, Maiken Stilling   +3 more
doaj   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

MicroRNA-421 affects the chemotaxis of monocytes via MCP-1, and regulates the local immune responses in injured cartilage site of elbow joint of upper limbs

Biotechnology & Biotechnological Equipment, 2020
The aim of the present study was to determine the expression of MCP-1 in injured cartilage tissues, peripheral blood and synovial fluid from patients with cartilage injury of elbow joint of upper limbs, and try to understand its relationship with ...
Feng Zhu, Jie Yin, Junjie Li, Jianbo Xue
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source