Results 71 to 80 of about 17,128,221 (391)

Discussion of "Bayesian Models and Methods in Public Policy and Government Settings" by S. E. Fienberg

open access: yes, 2011
Fienberg convincingly demonstrates that Bayesian models and methods represent a powerful approach to squeezing illumination from data in public policy settings.
Hand, David J.
core   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

open access: yesFEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Knockdown of LMX1B Suppressed Cell Apoptosis and Inflammatory Response in IL-1β-Induced Human Osteoarthritis Chondrocytes through NF-κB and NLRP3 Signal Pathway

open access: yesMediators of Inflammation, 2022
Osteoarthritis (OA), a chronic degenerative joint disease, always occurred in the aging population. There is evidence suggests that chondrocytes’ survival, inflammation, and apoptosis play critical roles in OA pathogenesis.
Yiping Mu, Lining Wang, Ling Fu, Qi Li
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

open access: yesFEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang   +9 more
wiley   +1 more source

Efficacy analysis of minimally invasive surgery for Raynaud’s syndrome

open access: yesBMC Surgery, 2023
Background Raynaud’s syndrome (RS), also referred to as Raynaud’s phenomenon, is a vasospastic disorder causing episodic color changes in extremities upon exposure to cold or stress.
Fengwei Yu   +7 more
doaj   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

open access: yesFEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira   +3 more
wiley   +1 more source

John Terrane: A Study of a First World War Revisionist [PDF]

open access: yes, 2012
Of all the British military historians who started writing about the First World War during the boom of the sixties, perhaps no one has had greater influence or generated more controversy than John Alfred Terraine. As G.F. Elliot wrote in a 1965 review,
Hand, Christopher M.
core   +1 more source

Rape myth acceptance, victim blame attribution and Just World Beliefs: a rapid evidence assessment [PDF]

open access: yes, 2017
Background: Rape is underreported, potentially because individuals self-blame and/or are blamed by others. Research predominantly illustrates male-perpetrated stranger-rape of females; thus, there may be a perception that rape myth acceptance (RMA) and
Hand, Christopher J.   +1 more
core   +2 more sources

The paradox of inequality: income inequality and belief in meritocracy go hand in hand

open access: yesSocio-Economic Review, 2019
Inequality is on the rise: gains have been concentrated with a small elite, while most have seen their fortunes stagnate or fall. Despite what scholars and journalists consider a worrying trend, there is no evidence of growing popular concern about ...
J. Mijs
semanticscholar   +1 more source

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