Results 31 to 40 of about 730,433 (314)

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Association between handgrip strength and physical activity in hypertensive elderly individuals

Revista Brasileira de Geriatria e Gerontologia
Introduction : Handgrip is an excellent indicator of functionality, nutritional status and mortality among the elderly. Objective: To compare the handgrip strength of hypertensive elderly individuals classified by different levels and types of physical ...
Rafaela Ávila Mattioli, Adriana Schüler Cavalli, José Antônio Bicca Ribeiro, Marcelo Cozzensa da Silva   +3 more
doaj   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

A Cross-sectional Study on Grip Ability Test and its Relation with “Hy” Band: Surrogate Marker for Amyloidosis in Patients with Rheumatoid Arthritis [PDF]

Journal of Clinical and Diagnostic Research, 2019
Introduction: Rheumatoid Arthritis (RA) is a chronic inflammatory disease of autoimmune origin. The disease has specific predilection for small joints of the body especially joints of the hand.
KR Senthil Kumari, GJ Swetha Varsha
doaj   +1 more source

Predicting maximal grip strength using hand circumference

Manual Therapy, 2010
The objective of this study was to analyze the correlations between anthropometric data and maximal grip strength (MGS) in order to establish a simple model to predict "normal" MGS. Randomized bilateral measurement of MGS was performed on a homogeneous population of 100 subjects.
Li, Ke, Hewson, David, Duchêne, Jacques, Hogrel, Jean-Yves   +3 more
openaire   +5 more sources

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Respiratory Function And Muscular Capacity In Old Adults: The Aga@4Life Project [PDF]

Geriatrics, Gerontology and Aging
INTRODUCTION: Age-related muscle changes, translated into a decrease both in muscle imass and functionality, are determinants of a decrease in strength and resistance to exercise in older adults.
Daniel Alexandre Dias Pedroso, Telmo Pereira, Jorge Conde   +2 more
doaj   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Investigating the effect of the Dominant Hand on Grip Strength and Hand Dexterity [PDF]

بهداشت و ایمنی کار
Introduction: In all societies, tools and equipment are generally designed for right-handed people, who make up approximately 90% of the population, but left-handed and ambidextrous people (those who use both hands in manual activities) also live among ...
Mohammad Sadegh Sohrabi, Atousa Rezayi, Tayeb Mohammadi, Mehrane Shabani   +3 more
doaj