Results 31 to 40 of about 753,167 (262)

Association between handgrip strength and physical activity in hypertensive elderly individuals

Revista Brasileira de Geriatria e Gerontologia
Introduction : Handgrip is an excellent indicator of functionality, nutritional status and mortality among the elderly. Objective: To compare the handgrip strength of hypertensive elderly individuals classified by different levels and types of physical ...
Rafaela Ávila Mattioli, Adriana Schüler Cavalli, José Antônio Bicca Ribeiro, Marcelo Cozzensa da Silva   +3 more
doaj   +1 more source

Serum Myonectin Levels Are Positively Associated With Physical Function and Lower Frailty‐Related Limitation in Maintenance Hemodialysis Patients: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Maintenance hemodialysis (MHD) patients frequently suffer from frailty, characterized by reduced physical function and poor prognosis. Myokines, such as myonectin, secreted by muscle, are emerging regulators of systemic health. This study investigated the relationship between serum myonectin, adipokines (adiponectin, omentin), and ...
Kenichi Kono, Yoshifumi Moriyama, Koji Ohashi, Naoya Otaka, Minako Tatsumi, Toyoaki Murohara, Noriyuki Ouchi, Satoru Oshima   +7 more
wiley   +1 more source

Assessment of maximal isometric hand grip strength in school-aged children

Open Medicine, 2018
Hand grip strength (HGS) test is commonly used as an indicator of overall muscle strength in medical and sport practices. Recently, several studies have proposed that the measurement of the maximal HGS depends on dynamometer’s handle position. The aim of
Gąsior Jakub S., Pawłowski Mariusz, Williams Craig A., Dąbrowski Marek J., Rameckers Eugene A.   +4 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Evaluación de factores asociados al estado funcional en ancianos de 60 años o más en Bogotá, Colombia

Biomédica: revista del Instituto Nacional de Salud, 2017
Introducción. La declinación funcional produce un amplio espectro de efectos negativos, como dificultad para la movilidad, aislamiento social, deterioro de la calidad de vida, discapacidad e internación en instituciones especializadas, lo cual convierte ...
Carlos Cano-Gutiérrez, Miguel Germán Borda, Carlos Reyes-Ortiz, Antonio J. Arciniegas, Rafael Samper-Ternent   +4 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Investigating the effect of the Dominant Hand on Grip Strength and Hand Dexterity [PDF]

بهداشت و ایمنی کار
Introduction: In all societies, tools and equipment are generally designed for right-handed people, who make up approximately 90% of the population, but left-handed and ambidextrous people (those who use both hands in manual activities) also live among ...
Mohammad Sadegh Sohrabi, Atousa Rezayi, Tayeb Mohammadi, Mehrane Shabani   +3 more
doaj  

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Correlation between handgrip strength and carrying angle in young women with different body mass indices – A cross-sectional observation study

Revista Pesquisa em Fisioterapia
| INTRODUCTION: Hand grip strength is an indicator to predict the health status of individuals in clinical practice. Age, gender, anthropometric characteristics, and health status influence grip strength performance of the hand through their influence on
Kshama Susheel Shetty, Rashmi Ravi Kotennavar, Hariharasudhan Ravichandran   +2 more
doaj   +1 more source