Results 101 to 110 of about 119,246 (323)

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Spiral phyllotaxis predicts left-right asymmetric growth and style deflection in mirror-image flowers of Cyanella alba

Nature Communications
Many animals and plants show left-right (LR) asymmetry. The LR asymmetry of mirror-image flowers has clear functional significance, with the reciprocal placement of male and female organs in left- versus right-handed flowers promoting cross-pollination ...
Caroline Robertson, Haoran Xue, Marco Saltini, Alice L. M. Fairnie, Dirk Lang, Merijn H. L. Kerstens, Viola Willemsen, Robert A. Ingle, Spencer C. H. Barrett, Eva E. Deinum, Nicola Illing, Michael Lenhard   +11 more
doaj   +1 more source

Broadband transparent chiral mirrors: Design methodology and bandwidth analysis

AIP Advances, 2019
Chiral mirrors are a class of metamaterials that reflect circularly polarized light of a certain helicity in a handedness-preserving manner, while absorbing circular polarization of the opposite handedness.
Wending Mai, Danny Zhu, Zheng Gong, Xiaoyou Lin, Yifan Chen, Jun Hu, Douglas H. Werner   +6 more
doaj   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

The Relationship between Handedness and Mathematics Is Non-linear and Is Moderated by Gender, Age, and Type of Task

Frontiers in Psychology, 2017
The relationship between handedness and mathematical ability is still highly controversial. While some researchers have claimed that left-handers are gifted in mathematics and strong right-handers perform the worst in mathematical tasks, others have more
Giovanni Sala, Michela Signorelli, Giulia Barsuola, Martina Bolognese, Fernand Gobet   +4 more
doaj   +1 more source

Geodesic flow, left-handedness, and templates

, 2014
We establish that, for every hyperbolic orbifold of type (2, q, $\infty$) and for every orbifold of type (2, 3, 4g+2), the geodesic flow on the unit tangent bundle is left-handed.
Arnol’d, Baader, Ghrist, Kaiser, Pierre Dehornoy   +4 more
core   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Testing the left-handedness of theb→ctransition [PDF]

, 2007
Benjamin M. Dassinger, Robert Feger, Thomas Mannel   +2 more
openalex   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source