Results 61 to 70 of about 40,694 (302)
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
Nutrition and handgrip strength of older adults in rural Malawi. [PDF]
, 2001 OBJECTIVE: To examine the relationship between the nutritional status and handgrip strength of older people in rural Malawi. DESIGN: Cross-sectional study. SETTING: : Lilongwe rural, Malawi, situated approximately 35-50 km from the city. SUBJECTS: Ninety
Ismail, SJ, Chilima, DM
core +1 more source
Studi Kasus Penerapan Teknik Handgrip Exercise Terhadap Penurunan Tekanan Darah [PDF]
, 2023 Hipertensi merupakan keadaan dimana tekanan darah meningkat melebihi batas normal dengan tekanan sistolik140mmHg dan tekanan darah diastolik 90 mmHg. Salah satu gejala yang dapat timbul dalam peningkatan tekanan darah berupa nyeri kepala.
Agstri Dwi Marsela +3 more
core +1 more source
The eEgg: Evaluation of a New Device to Measure Pain
Frontiers in Physiology, 2022 Aim: The aim of this study was to evaluate whether pain stimuli can be measured validly and reliably by the eEgg (electronic Egg), a new device to measure pain intensity, in comparison to the hand dynamometer.Methods: This study consists of screening and
Dshamilja M. Böing-Meßing +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Association between handgrip and anemia.
, 2020 Association between handgrip and anemia.
Boyoung Jung (4908229) +4 more
core +1 more source
Facial masculinity is only weakly correlated with handgrip strength in young adult women [PDF]
, 2018 Objectives: Ancestrally, strength is likely to have played a critical role in determining the ability to obtain and retain resources and the allocation of social status among humans. Responses to facial cues of strength are therefore thought to play an
O'Shea, Kieran J. +23 more
core +1 more source