Results 81 to 90 of about 40,694 (302)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Paddle grip : handgrip size ratio and associated factors contributing to the development of lateral elbow tendinosis and DeQuervains tenosynovitis in K1 marathon paddlers during the 2006 Berg River Canoe Marathon

, 2009
Includes abstract.Includes bibliographical references (leaves 98-105).Aim: To determine the relationship between the paddle grip: handgrip size ratio and associated factors contributing to the development of lateral elbow tendinosis and DeQuervains ...
Viviers, Wendy
core  

Moderation Effect of Handgrip Strength on Cognition and Functional Independence Associations in Adults Over 90 Years

Journal of Cachexia, Sarcopenia and Muscle
Introduction The causal relationship between cognitive impairment and functional decline seems bidirectional in older adults. This study aimed to determine the moderating effect of handgrip strength on the relationship between cognition and functional ...
Mikel L. Sáez de Asteasu, Eduardo L. Cadore, Tainara Steffens, Eduarda Blanco‐Rambo, Talita Molinari, Marcelo Bandeira‐Guimaraes, Mikel Izquierdo, Caroline Pietta‐Dias   +7 more
doaj   +1 more source

Baroreflex Coupling Assessed by Cross-Compression Entropy

Frontiers in Physiology, 2017
Estimating interactions between physiological systems is an important challenge in modern biomedical research. Here, we explore a new concept for quantifying information common in two time series by cross-compressibility.
Andy Schumann, Steffen Schulz, Andreas Voss, Susann Scharbrodt, Mathias Baumert, Karl-Jürgen Bär   +5 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Cutaneous vascular responses to isometric handgrip exercise

, 1989
Cutaneous vascular responses to dynamic exercise have been well characterized, but it is not known whether that response pattern applies to isometric handgrip exercise.
W. A. Kosiba, J. M. Johnson, C. M. Kwan, W. F. Taylor   +3 more
core   +1 more source

Is Handgrip Strength a Useful Measure to Evaluate Lower Limb Strength and Functional Performance in Older Women?

Clinical Interventions in Aging, 2020
Andre Luiz Felix Rodacki,1 Natália Boneti Moreira,2 Arthur Pitta,1 Renata Wolf,1 Jarbas Melo Filho,1 Cintia de Lourdes Nahhas Rodacki,1,3 Gleber Pereira1 1Department of Physical Education, Federal University of Parana, Curitiba, Brazil ...
Rodacki ALF, Boneti Moreira N, Pitta A, Wolf R, Melo Filho J, Rodacki CLN, Pereira G   +6 more
doaj  

From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care

Molecular Oncology, EarlyView.
Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard, Flavie Bénard, Eva Billat, Margaux Le Guyon, Victoria Maltret, Laura Merlet, Chloé Astrid Walter, Tony Avril, Eric Chevet   +8 more
wiley   +1 more source

Handgrip Strength is Related to Bone Mineral Density in Male Athletes - Original Investigation

, 2009
Aim: The aim of this study was to investigate the relationship between handgrip strength and phalangeal bone mineral density (BMD) and to evaluate the confounding factors in highly trained male athletes.
Selmin Gülbahar, Ramazan Kızıl, Ebru Şahin, Elif Akalın, Özlem El, Serap Alper, Çiğdem Bircan, Aylin Çeçen Aksu, Şebnem Tamcı   +8 more
core