Results 71 to 80 of about 40,694 (302)

Handgrip Strength in Lung Transplant Candidates and Recipients

, 2023
Objectives: Handgrip strength is increasingly used to assess muscle strength in various conditions. In this review, we investigated handgrip strength in patients receiving or awaiting lung transplant.Materials and Methods: For this integrative review, we
Dell'Amore, Andrea, Reed, Robert M, Pehlivan, Esra, Polastri, Massimiliano   +3 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Peripheral vasoconstriction is not elevated during hyperreactive responses to the cold pressor test: a cross-sectional study

Frontiers in Physiology
BackgroundIndividuals demonstrating increases in systolic systolic blood pressure or diastolic diastolic blood pressure blood pressure of at least 15 mmHg are considered hyperreactors to the cold pressor test (CPT).
Jon Stavres, Anabelle Vallecillo-Bustos, Sarah Parnell, Ryan S. Aultman, Ta’Quoris A. Newsome, Sydney H. Swafford, Abby T. Compton, Rhett C. Schimpf, Sophia N. Schmidt, Carstell Lee, Austin J. Graybeal   +10 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Distinct Metabolomic Alterations Are Associated With Physical Function, Weight Loss, and Muscle Mass in Men With Cancer

Journal of Cachexia, Sarcopenia and Muscle
Background Treatments for cancer cachexia, defined as involuntary weight and muscle mass loss leading to significant functional impairment, remain unavailable partly due to insufficient improvement of clinically meaningful outcomes in current trials.
Lindsey J. Anderson, Lu Xia, Haiming Kerr, Marin Cabrera, Fabien Chu, Jaqueline Rose, Peter C. Wu, Atreya Dash, Sina A. Gharib, Jose M. Garcia   +9 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Cardiac baroreflex sensitivity during repeated handgrip exercise: Comparisons with sit‐stand maneuvers and spontaneous rest

Physiological Reports
The cardiac baroreflex regulates arterial pressure via autonomic heart rate control. While sit‐stand maneuvers (SSM) have been used to assess baroreflex sensitivity (BRS), they may be impractical for physically immobile individuals.
Wenxing Qin, Marina Fukuie, Daisuke Hoshi, Shoya Mori, Tsubasa Tomoto, Shigehiko Ogoh, Jun Sugawara, Takashi Tarumi   +7 more
doaj   +1 more source

Subcutaneous Adipose Tissue in Female Volleyball Players: Is It Related with Performance Indices?

Medicina, 2020
Background and objectives: The aim of the present study was to examine subcutaneous adipose tissue distribution in female volleyball players with regards to (a) variation by anatomical site, (b) differences among age groups and playing positions, and (c)
Sophia D. Papadopoulou, Amalia Zorzou, Antonio Garcia-de-Alcaraz, Thomas Rosemann, Beat Knechtle, Pantelis T. Nikolaidis   +5 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source