Results 61 to 70 of about 18,586 (269)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Improving Model Performance for Predicting Exfiltration Attacks Through Resampling Strategies
International Islamic University Malaysia Engineering JournalAddressing class imbalance is critical in cybersecurity applications, particularly in scenarios like exfiltration detection, where skewed datasets lead to biased predictions and poor generalization for minority classes.
Arif Rahman Hakim +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.This research protocol outlines a workflow for nuclear magnetic resonance (NMR)‐based metabolomics in the agri‐food sector. Using two case studies—strawberry leaves (solid matrix) and wine (liquid matrix)—it details the procedures for sample preparation, data acquisition, and processing.
Andrea Fernández‐Veloso +4 more
wiley +1 more source
GMDH2: Binary Classification via GMDH-Type Neural Network Algorithms—R Package and Web-Based Tool
International Journal of Computational Intelligence SystemsGroup method of data handling (GMDH)-type neural network algorithms are the self-organizing algorithms for modeling complex systems. GMDH algorithms are used for different objectives; examples include regression, classification, clustering, forecasting ...
Osman Dag, Erdem Karabulut, Reha Alpar
doaj +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
Scientific ReportsWorldwide, coronary heart disease (CHD) is a leading cause of mortality, and its early prediction remains a critical challenge in clinical data analysis.
Moiz Ur Rehman +7 more
doaj +1 more source
Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
FEBS Open Bio, EarlyView.Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
wiley +1 more source
An Improved Algorithm for Bayes Classifier to Handle Correlated Attributes
International Journal of Computer Applications, 2013 Classification can be defined as a target function which maps attribute value of objects to predefined class. One objective is to divide the objects into proper group and other objective is to predict the class of unknown records. Bayesian classifier classifies and predicts the class of objects on the basis of posterior probability based on some prior ...
Kshitij Pathak, Sharmishtha Panagare
openaire +1 more source
FEBS Open Bio, EarlyView.In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes +32 more
wiley +1 more source
Screening and epitope characterization of Nidogen‐2‐specific nanobodies
FEBS Open Bio, EarlyView.Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen +9 more
wiley +1 more source