Results 51 to 60 of about 163,035 (312)

Novice Ideas: Handwriting Comparisons Conducted by an Untrained Individual [PDF]

open access: yes, 2019
Forensic analysis of questioned documents includes chemical analyses of paper and ink as well as handwriting comparisons. Several elements affect handwriting analyses, including the presence of discriminatory factors that can individualize a handwriting ...
Lister, Maia
core   +1 more source

Handwriting styles: benchmarks and evaluation metrics

open access: yes, 2018
Evaluating the style of handwriting generation is a challenging problem, since it is not well defined. It is a key component in order to develop in developing systems with more personalized experiences with humans.
Bailly, Gerard   +2 more
core   +1 more source

A Unified Multilingual Handwriting Recognition System using multigrams sub-lexical units [PDF]

open access: yes, 2018
We address the design of a unified multilingual system for handwriting recognition. Most of multi- lingual systems rests on specialized models that are trained on a single language and one of them is selected at test time.
Paquet, Thierry   +2 more
core   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Handwriting analysis for diagnosis and prognosis of Parkinson’s disease [PDF]

open access: yes, 2010
At present, there are no quantitative, objective methods for diagnosing the Parkinson disease. Existing methods of quantitative analysis by myograms suffer by inaccuracy and patient strain; electronic tablet analysis is limited to the visible drawing ...
Brause, Rüdiger W.   +2 more
core  

How to use pen and paper tasks to aid tremor diagnosis in the clinic [PDF]

open access: yes, 2017
When a patient presents with tremor, it can be useful to perform a few simple pen and paper tests. In this article, we explain how to maximise the value of handwriting and of drawing Archimedes spirals and straight lines as clinical assessments.
Deborah Thorpe   +3 more
core   +2 more sources

Handwriting identification: Challenges and solutions

open access: yesJournal of Forensic Science and Medicine, 2018
As a historic technology, handwriting identification, especially that of Chinese characters, plays an important role in judicial trials both in domestic and abroad. However, in recent decades, handwriting identification has faced a challenging situation;
Liu Xiaohong, Lian Yuanyuan
doaj   +1 more source

Higher risk for poor handwriting in Taiwanese children born late preterm

open access: yesPediatrics and Neonatology, 2023
Background: Late-preterm and early-term births constitute a significant proportion of live births. However, handwriting skills of these two populations remain unclear. We aimed to investigate their risk for poor Chinese handwriting in grade two. Methods:
Yea-Shwu Hwang   +3 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

open access: yesMolecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad   +12 more
wiley   +1 more source

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