Results 61 to 70 of about 153,487 (228)

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

ZONING DESIGN FOR HAND­WRITTEN NUMERAL RECOGNITION [PDF]

open access: yes, 1997
Microsoft, Motorola, Siemens, Hitachi, IAPR, NICI, IUF In the field of Optical Character Recognition (OCR), zoning is used to extract topological information from patterns. In this paper zoning is considered as the result of an optimisation problem and a
Dimauro, G.   +5 more
core   +2 more sources

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

open access: yesFEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru   +6 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Relationship between Handwriting and Visual-Motor Integration in Primary School

open access: yesPsicología Educativa: Revista de los Psicólogos de la Educación
Introduction: School-based literacy development involves the acquisition of complex cognitive and motor skills, among which handwriting plays a central role.
Mariana Diez, Ramón Álvarez-Vaz
doaj   +1 more source

The Models of Authority Project: Extending the DigiPal Framework for Script and Decoration [PDF]

open access: yes, 2016
The DigiPal project for palaeography has featured in previous DH conferences. It includes a generalised framework for the description and analysis of handwriting, initially applied to Old English of the eleventh century but subsequently extended to Latin,
Brookes, Stewart   +7 more
core  

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

open access: yesFEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda   +12 more
wiley   +1 more source

Forensic study on the effect of age and illness (Parkinsonism) on handwriting characteristics

open access: yesEgyptian Journal of Forensic Sciences, 2019
Background Handwriting is a neuromuscular task. Old age and illness may produce significant deteriorating effects on the quality of handwriting/signatures of an individual. In some cases, the affected writings may be suspected of being forged due to poor
Komal Saini, Manpreet Kaur
doaj   +1 more source

Handwritten Arabic character recognition: which feature extraction method? [PDF]

open access: yes, 2011
Recognition of Arabic handwriting characters is a difficult task due to similar appearance of some different characters. However, the selection of the method for feature extraction remains the most important step for achieving high recognition accuracy ...
Angelova, Maia   +3 more
core  

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