Results 61 to 70 of about 187,759 (326)
Emerging role of ARHGAP29 in melanoma cell phenotype switching
Molecular Oncology, EarlyView.This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster +3 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Research on subjective bias cognition effect in handwriting identification
Journal of Forensic Science and Medicine, 2018 This article starts from the point of view that handwriting examination is dependent on empiricism and by analyzing the core steps of handwriting identification explains that it might be influenced by subjective bias.
Bing Li, Tiantian Ma
doaj +1 more source
Haptic guidance improves the visuo-manual tracking of trajectories [PDF]
, 2008 BACKGROUND: Learning to perform new movements is usually achieved by following visual demonstrations. Haptic guidance by a force feedback device is a recent and original technology which provides additional proprioceptive cues during visuo-motor learning
Chris Miall +23 more
core +6 more sources
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
IEEE Reviews in Biomedical Engineering, 2019 Neurodegenerative diseases, for instance Alzheimer's disease (AD) and Parkinson's disease (PD), affect the peripheral nervous system, where nerve cells send messages that control muscles in order to allow movements.
D. Impedovo, G. Pirlo
semanticscholar +1 more source
Handwriting styles: benchmarks and evaluation metrics
, 2018 Evaluating the style of handwriting generation is a challenging problem, since it is not well defined. It is a key component in order to develop in developing systems with more personalized experiences with humans.
Bailly, Gerard +2 more
core +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Novice Ideas: Handwriting Comparisons Conducted by an Untrained Individual [PDF]
, 2019 Forensic analysis of questioned documents includes chemical analyses of paper and ink as well as handwriting comparisons. Several elements affect handwriting analyses, including the presence of discriminatory factors that can individualize a handwriting ...
Lister, Maia
core +1 more source