Results 31 to 40 of about 10,624 (261)

Relationship between Handwriting and Visual-Motor Integration in Primary School

Psicología Educativa: Revista de los Psicólogos de la Educación
Introduction: School-based literacy development involves the acquisition of complex cognitive and motor skills, among which handwriting plays a central role.
Mariana Diez, Ramón Álvarez-Vaz
doaj   +1 more source

On the Issue of Forensic Analysis of the Images of Handwriting Objects

Теория и практика судебной экспертизы, 2022
The article highlights the current issues of forensic analysis of images of manuscripts. The authors describe these objects of forensic handwriting expertise, highlight their distinctive features.
S. M. Bobovkin, O. A. Didenko
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Reliability and validity of Handwriting Test for Preschool Children (HT-PRE): A new tool to assess the handwriting ability of preschool children aged 5-6 years old in Mainland China.

PLoS ONE, 2020
BACKGROUND:Handwriting ability is related to many neuronal functions, such as visual-perceptual skills, orthographic coding, motor planning and execution, kinesthetic feedback and visual-motor coordination.
Qin Hong, Bei Jiang, Qu Xu, Lei Zhang, Jiaxin Ou, Qingyu Zhang, Nan Li, Jing Wang, Yachun Xie, Jing Hua, Xirong Guo, Meiling Tong, Xia Chi   +12 more
doaj   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Writing the Future: Artificial Intelligence, Handwriting, and Early Biomarkers for Parkinson’s Disease Diagnosis and Monitoring

Biomedicines
Parkinson’s disease (PD) is a progressive neurodegenerative disorder that impairs motor function, including the fine motor control required for handwriting.
Giuseppe Marano, Sara Rossi, Ester Maria Marzo, Alice Ronsisvalle, Laura Artuso, Gianandrea Traversi, Antonio Pallotti, Francesco Bove, Carla Piano, Anna Rita Bentivoglio, Gabriele Sani, Marianna Mazza   +11 more
doaj   +1 more source

Forensic examination of effects of rheumatoid arthritis on handwriting characteristics

Egyptian Journal of Forensic Sciences, 2021
Background Rheumatoid arthritis is known to produce deformity of the joints and muscles which can affect the handwriting of an individual significantly.
Komal Saini, Bhavya Sharma, Manpreet Kaur   +2 more
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Major depressive disorder recognition based on electronic handwriting recorded in psychological tasks

BMC Medicine
Background This study aimed to determine whether handwriting patterns are altered in individuals experiencing depressive episodes. Additionally, we developed a model for the recognition of major depressive disorder (MDD) based on electronic handwriting ...
Chong Li, Kunxue Zhang, Qunxing Lin, Shan Huang, Wanying Cheng, Yueshiyuan Lei, Xinyu Zhao, Jiubo Zhao   +7 more
doaj   +1 more source