Results 51 to 60 of about 14,024 (303)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Novel geometric features for off-line writer identification
, 2016 Writer identification is an important field in forensic document examination. Typically, a writer identification system consists of two main steps: feature extraction and matching and the performance depends significantly on the feature extraction step ...
Al-Maadeed, Somaya +3 more
core +1 more source
BMC MedicineBackground This study aimed to determine whether handwriting patterns are altered in individuals experiencing depressive episodes. Additionally, we developed a model for the recognition of major depressive disorder (MDD) based on electronic handwriting ...
Chong Li +7 more
doaj +1 more source
Frontiers in Computational Neuroscience, 2014 The remarkable abilities of the primate visual cortex have inspired the construction of computational models of some visual neurons. We propose a trainable hierarchical object recognition model, which we call S-COSFIRE (S stands for Shape and COSFIRE ...
George eAzzopardi, Nicolai ePetkov
doaj +1 more source
A study of auxiliary screening for Alzheimer’s disease based on handwriting characteristics
Frontiers in Aging Neuroscience, 2023 Background and objectivesAlzheimer’s disease (AD) has an insidious onset, the early stages are easily overlooked, and there are no reliable, rapid, and inexpensive ancillary detection methods.
Hengnian Qi +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
BiomedicinesParkinson’s disease (PD) is a progressive neurodegenerative disorder that impairs motor function, including the fine motor control required for handwriting.
Giuseppe Marano +11 more
doaj +1 more source
Tools and Methods for Diagnosing Developmental Dysgraphia in the Digital Age: A State of the Art
Children, 2023 Handwriting is a complex perceptual motor task that requires years of training and practice before complete mastery. Its acquisition is crucial, since handwriting is the basis, together with reading, of the acquisition of higher-level skills such as ...
Jérémy Danna +2 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Journal of Rehabilitation, 2007 Objective: Handwriting difficulty is a common problem in mentally-retarded students. This article investigates the relationship between handwriting and spatial analysis.
Fatemeh Hadavandkhani +4 more
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