Results 41 to 50 of about 10,624 (261)

Digital handwriting metrics and temporal behaviors for predicting early Alzheimer’s onset [PDF]

open access: yesExploration of Digital Health Technologies
Aim: The aim of this paper was to explore stroke-level handwriting dynamics as early behavioral biomarkers for Alzheimer’s disease (AD). Methods: Stroke-level handwriting data were collected from 174 participants (89 probable AD or mild cognitive ...
Charity Nyamuchengwa
doaj   +1 more source

A study of auxiliary screening for Alzheimer’s disease based on handwriting characteristics

open access: yesFrontiers in Aging Neuroscience, 2023
Background and objectivesAlzheimer’s disease (AD) has an insidious onset, the early stages are easily overlooked, and there are no reliable, rapid, and inexpensive ancillary detection methods.
Hengnian Qi   +7 more
doaj   +1 more source

Analysis and Remediation of Handwriting difficulties

open access: yes, 2020
Even with correct training, up to 25% of children never master handwriting like their peers. While research shows a correlation between handwriting difficulties and school failure, these difficulties can also impact children in their self esteem and behavioral development. Since the mastery of handwriting requires a lot of different skills, it is never
openaire   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Relationship between Spatial Analysis and Handwriting in Mentally-Retarded Students of Shah-e Rey (2006)

open access: yesJournal of Rehabilitation, 2007
Objective: Handwriting difficulty is a common problem in mentally-retarded students. This article investigates the relationship between handwriting and spatial analysis.
Fatemeh Hadavandkhani   +4 more
doaj  

Using a handwriting app leads to improvement in manual dexterity in kindergarten children

open access: yesResearch in Learning Technology, 2019
This study aimed to determine the effectiveness of using electronic handwriting applications (apps) in addition to a traditional method of teaching handwriting on kindergarten children’s manual dexterity (MD) and handwriting skills. Testing was done with
Christi Butler   +4 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

open access: yesFEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong   +3 more
wiley   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

open access: yesFEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro   +1 more
wiley   +1 more source

Home - About - Disclaimer - Privacy