Results 1 to 10 of about 303,688 (221)

Mapping Haplotype-haplotype Interactions with Adaptive LASSO [PDF]

BMC Genetics, 2010
Background The genetic etiology of complex diseases in human has been commonly viewed as a complex process involving both genetic and environmental factors functioning in a complicated manner.
Li Ming, Romero Roberto, Fu Wenjiang J, Cui Yuehua   +3 more
doaj   +3 more sources

A Common Variant Associated with Dyslexia Reduces Expression of the KIAA0319 Gene [PDF]

, 2009
Numerous genetic association studies have implicated the KIAA0319 gene on human chromosome 6p22 in dyslexia susceptibility. The causative variant(s) remains unknown but may modulate gene expression, given that (1) a dyslexia-associated haplotype has been
Megan Y. Dennis, Silvia Paracchini, Thomas S. Scerri, Ludmila Prokunina-Olsson, Julian C. Knight, Richard Wade-Martins, Penny Coggill, Stephan Beck, Eric D. Green, Anthony P. Monaco, Lisa Stubbs, SE Fisher, SE Shaywitz, SE Shaywitz, JC DeFries, JC DeFries, JM Finucci, JW Gilger, JC DeFries, M Taipale, TS Scerri, KG Wigg, K Hannula-Jouppi, H Meng, J Schumacher, C Francks, N Cope, D Harold, M Luciano, S Paracchini, H Anthoni, AM Galaburda, GD Rosen, SW Threlkeld, Y Wang, TJ Burbridge, S Paracchini, AM Galaburda, AJ Marlow, SE Fisher, GR Abecasis, JC Barrett, S Schwartz, NG Copeland, S Warming, GH Perdew, DC King, J Taylor, JW Thomas, A Visel, WJ Kent, AE Kel, R Kageyama, PI Lin, S Paracchini, JA Fiez, P Swoboda, R Dubruille, M Gotz, KY Chau, JD Klemm, RA Sturm, T Kiyota, MK Kim, J Bode, E Birney, JC Knight, T Pastinen   +67 more
core   +10 more sources

Global Analysis of Plasmodium falciparum Dihydropteroate Synthase Variants Associated with Sulfadoxine Resistance Reveals Variant Distribution and Mechanisms of Resistance: A Computational-Based Study

Molecules, 2022
The continual rise in sulfadoxine (SDX) resistance affects the therapeutic efficacy of sulfadoxine-pyrimethamine; therefore, careful monitoring will help guide its prolonged usage.
Rita Afriyie Boateng, James L. Myers-Hansen, Nigel N. O. Dolling, Benedicta A. Mensah, Elia Brodsky, Mohit Mazumder, Anita Ghansah   +6 more
doaj   +1 more source

Superior Haplotypes for Early Root Vigor Traits in Rice Under Dry Direct Seeded Low Nitrogen Condition Through Genome Wide Association Mapping

Frontiers in Plant Science, 2022
Water and land resources have been aggressively exploited in the recent decades to meet the growing demands for food. The changing climate has prompted rice scientists and farmers of the tropics and subtropics to adopt the direct seeded rice (DSR) system.
Annamalai Anandan, Annamalai Anandan, Siddharth Panda, Siddharth Panda, S. Sabarinathan, Anthony J. Travis, Gareth J. Norton, Adam H. Price   +7 more
doaj   +1 more source

Detecting Local Haplotype Sharing and Haplotype Association [PDF]

Genetics, 2014
Abstract A novel haplotype association method is presented, and its power is demonstrated. Relying on a statistical model for linkage disequilibrium (LD), the method first infers ancestral haplotypes and their loadings at each marker for each individual.
Xu, Hanli, Guan, Yongtao
openaire   +2 more sources

Joint Haplotype Assembly and Genotype Calling via Sequential Monte Carlo Algorithm [PDF]

, 2015
Genetic variations predispose individuals to hereditary diseases, play important role in the development of complex diseases, and impact drug metabolism. The full information about the DNA variations in the genome of an individual is given by haplotypes,
Ahn, Soyeon, Vikalo, Haris
core   +3 more sources

Exploring effective approaches for haplotype block phasing

BMC Bioinformatics, 2019
Background Knowledge of phase, the specific allele sequence on each copy of homologous chromosomes, is increasingly recognized as critical for detecting certain classes of disease-associated mutations. One approach for detecting such mutations is through
Ziad Al Bkhetan, Justin Zobel, Adam Kowalczyk, Karin Verspoor, Benjamin Goudey   +4 more
doaj   +1 more source

Analysis of the mtDNA D-loop Region Casts New Light on Philippine Red Junglefowl Phylogeny and Relationships to Other Junglefowl Species in Asia

The Journal of Poultry Science, 2022
Red junglefowl (RJF) is considered the ancestor of domestic chickens. However, the possible maternal origin, genetic diversity, and subspecies classification of the Philippine (PH) RJF remains uncertain.
Jade Dhapnee Z. Compendio, Jam Marrie Nanche P. Mantana, Masahide Nishibori   +2 more
doaj   +1 more source

Haplotype analysis of genomic prediction by incorporating genomic pathway information based on high-density SNP marker in Chinese yellow-feathered chicken

Poultry Science, 2023
: Genomic selection using single nucleotide polymorphism (SNP) markers is now intensively investigated in breeding and has been widely utilized for genetic improvement.
Haoqiang Ye, Zhenqiang Xu, Semiu Folaniyi Bello, Qianghui Zhu, Shaofen Kong, Ming Zheng, Xiang Fang, Xinzheng Jia, Haiping Xu, Xiquan Zhang, Qinghua Nie   +10 more
doaj   +1 more source

Inactive alleles of cytochrome P450 2C19 may be positively selected in human evolution Genome evolution and evolutionary systems biology [PDF]

, 2014
© 2014 Janha et al.; licensee BioMed Central Ltd.Background: Cytochrome P450 CYP2C19 metabolizes a wide range of pharmacologically active substances and a relatively small number of naturally occurring environmental toxins.
Janha, RE, Linton, KJ, Shaheen, SO, Sisay-Joof, F, Walton, RT, Worwui, A   +5 more
core   +3 more sources