Results 131 to 140 of about 407,509 (363)

A General Approach for Haplotype Phasing across the Full Spectrum of Relatedness

PLoS Genetics, 2014
Many existing cohorts contain a range of relatedness between genotyped individuals, either by design or by chance. Haplotype estimation in such cohorts is a central step in many downstream analyses.
Jared O'Connell, D. Gurdasani, Olivier Delaneau, N. Pirastu, Sheila Ulivi, M. Cocca, M. Traglia, Jie Huang, J. Huffman, I. Rudan, R. McQuillan, Ross M. Fraser, H. Campbell, O. Polašek, G. Asiki, K. Ekoru, C. Hayward, A. Wright, V. Vitart, P. Navarro, J. Zagury, James F. Wilson, D. Toniolo, P. Gasparini, N. Soranzo, M. Sandhu, J. Marchini   +26 more
semanticscholar   +1 more source

The Role of Viral and Bacterial Infections in the Etiology of Behçet's Disease

Journal of Clinical Laboratory Analysis, EarlyView.
Bacterial and viral pathogens may play a key role in Behçet's disease (BD) pathogenesis by triggering autoimmunity, molecular mimicry, or microbiome disruption. These infectious agents could initiate inflammatory pathways, contributing to BD's diverse clinical manifestations.
Mohsen Moghoofei, Hamid Pajavand, Razieh Shahbazi, Marzieh Rezaei, Elahe Taki   +4 more
wiley   +1 more source

Genome-wide haplotype-based association analysis of major depressive disorder in Generation Scotland and UK Biobank [PDF]

, 2017
David M. Howard, Lynsey S. Hall, Jonathan D. Hafferty, Yanni Zeng, Mark J. Adams, Toni‐Kim Clarke, David J. Porteous, Réka Nagy, Caroline Hayward, Blair H. Smith, Alison D. Murray, Niamh Ryan, Kathryn L. Evans, Chris Haley, Ian J. Deary, Pippa A. Thomson, Andrew M. McIntosh   +16 more
openalex   +1 more source

Of Genes, Blocks, and Haplotypes [PDF]

Biology of Blood and Marrow Transplantation, 2012
indicate normal function. Today, functional assays such as with tetramer staining, intracellular cytokine staining, and degranulation assays, are becoming more readily available and allow us to functionally interrogate lymphocyte subpopulations. These assessments, if validated as predictors of infection and relapse, will not only help elucidate the ...
openaire   +2 more sources

Genome‐wide association study of periodontitis severity and progression

Journal of Periodontology, EarlyView.
Abstract Background To add to the knowledge base of periodontal genomics, we carried out a genome‐wide association study (GWAS) of periodontitis severity and progression among 416 mixed‐ethnicity adult participants of a periodontitis clinical study. Methods Participants were 168 adults (mean age = 50 years, 46% males) with severe periodontitis and 248 ...
Flavia Teles, Ganesh Chandrasekaran, Lynn Martin, Poojan Shrestha, Kevin Moss, Michele Patel, Michael J. Kallan, Camila Furquim, Andrew J. Cucchiara, James D. Beck, Kari E. North, Joseph Glessner, Kimon Divaris   +12 more
wiley   +1 more source

Mitochondrial and Y chromosome haplotype motifs as diagnostic markers of Jewish ancestry: a reconsideration.

Frontiers in Genetics, 2014
Several authors have proposed haplotype motifs based on site variants at the mitochondrial genome (mtDNA) and the non-recombining portion of the Y chromosome (NRY) to trace the genealogies of Jewish people.
Sergio eTofanelli, Luca eTaglioli, Stefania eBertoncini, Paolo eFrancalacci, Anatole eKlyosov, Luca ePagani, Luca ePagani   +6 more
doaj   +1 more source

The extreme plasticity of killer cell Ig‐like receptor (KIR) haplotypes differentiates rhesus macaques from humans [PDF]

, 2011
Jeroen H. Blokhuis, Marit K. van der Wiel, Gaby G. M. Doxiadis, Ronald E. Bontrop   +3 more
openalex   +1 more source

HLA DQ2/DQ8 haplotypes and anti-transglutaminase antibodies as celiac disease markers in a pediatric population with type 1 diabetes mellitus [PDF]

, 2022
Diana Rita Oliveira, Joana Freitas Rebelo, Cristiana Maximiano, Maria Miguel Gomes, Vânia Martins, Carla Meireles, Henedina Antunes, Sofia Martıns   +7 more
openalex   +1 more source

A set of serum proteomic biomarkers differentiates celiac children from age and human leukocyte antigen‐matched healthy controls

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objective The latest European Society of Gastroenterology Hepatology and Nutrition (ESPGHAN) criteria for celiac disease (CD) diagnosis reduced the requirement for a small intestinal biopsy but still, for most of the cases a small intestinal biopsy is required for a safe diagnosis: hence the attempt to identify serum biomarkers that could ...
Roberta Mandile, Michele Francesco di Tolla, Martina Carpinelli, Janneke Nicoline Samsom, Rossella De Cegli, Maria Vittoria Barone, Riccardo Troncone, Pietro Formisano, Luigi Greco, Renata Auricchio   +9 more
wiley   +1 more source

Autoantibody signatures in children with celiac disease, juvenile idiopathic arthritis, and polyautoimmunity

JPGN Reports, EarlyView.
Abstract Objective To determine if multiplex autoantibody arrays can identify novel biomarker signatures in children with one or multiple autoimmune diseases (polyautoimmunity). Methods Plasma collected from children (18 years or younger) in the Boston Children's Hospital Precision Link Biobank for Health Discovery between January 2007 and June 2021 ...
Nan Du, Denis Chang, Madison Wong, Jay R. Thiagarajah, Erin Janssen, Lauren A. Henderson, Krishnan Raghunathan, Jocelyn A. Silvester   +7 more
wiley   +1 more source