Results 111 to 120 of about 28,399 (219)

Does Next Generation Sequencing (NGS)‐Based CYP2D6 Sequencing Improve Genotype–Phenotype Concordance in Tamoxifen‐Treated Patients?

Clinical Pharmacology &Therapeutics, EarlyView.
CYP2D6 metabolizes about 20% of commonly used drugs, including tamoxifen, a major hormone therapy for breast cancer. Although the relationship between tamoxifen pharmacokinetics and CYP2D6 genotype has been demonstrated, residual variability in drug exposure remains unexplained.
Jeanne Petit, Julien Plenecassagnes, Aurelie Brice, Florence Dalenc, Ludovic Mallet, Etienne Chatelut, Ayman Al Saati, Fabienne Thomas   +7 more
wiley   +1 more source

Haplotype frequency analysis of rs1778929. rs1187323.

, 2016
Haplotype frequency analysis of rs1778929. rs1187323.
Qian Yang (300330), Liang Ge (541067), Xianhui Ding (834253), Jia Hu (77170), Xianjin Shang (834254), Xianjun Huang (834255), Taofeng Zhou (834256), Zhiming Zhou (834252)   +7 more
core   +1 more source

Benchmark of Open‐Access Star‐Allele Callers to Accurately Assess Haplotypes and Phenotypes in Pharmacogenetic Studies

Clinical Pharmacology &Therapeutics, EarlyView.
Genetic polymorphisms are common in pharmacogenes, with sometimes important implications for drug metabolism. Assessing the correct enzyme phenotype from genetic data is thus a crucial step into the development of personalized medicine. Many bioinformatics star‐allele callers have been developed for this purpose of identifying the correct star alleles ...
Marc B. Gros‐La‐Faige, Emmanuelle Génin, Anthony F. Herzig   +2 more
wiley   +1 more source

Genome-wide association study and haplotype analyses reveal the genetic architecture of agronomic traits and sugars in sweet sorghum

Frontiers in Genetics
IntroductionSweet sorghum is a C4 tropical grass species that has gained importance quickly as a major bioenergy crop.MethodsThis genome-wide association study (GWAS) utilized a sweet sorghum panel (SSP) of 183 diverse sweet sorghum accessions genotyped ...
Abdullah Bin Umar, Ajay Prasanth Ramalingam, Bushra Sadia, Faisal Saeed Awan, Farooq Ahmad Khan, Mariam Nasir, Amy Bernardo, Paul St. Amand, Guihua Bai, P. V. Vara Prasad, Ramasamy Perumal   +10 more
doaj   +1 more source

Genetic dissection of major QTL for grain number per spike on chromosomes 5A and 6A in bread wheat (Triticum aestivum L.)

Frontiers in Plant Science
Grain number per spike (GNS) is a crucial component of grain yield and plays a significant role in improving wheat yield. To identify quantitative trait loci (QTL) associated with GNS, a recombinant inbred line (RIL) population derived from the cross of ...
Cheng Jiang, Cheng Jiang, Cheng Jiang, Zhibin Xu, Xiaoli Fan, Qiang Zhou, Guangsi Ji, Guangsi Ji, Simin Liao, Simin Liao, Yanlin Wang, Yanlin Wang, Fang Ma, Fang Ma, Yun Zhao, Tao Wang, Tao Wang, Bo Feng   +17 more
doaj   +1 more source

Distribution of haplotype analysis in study cohort.

, 2018
Distribution of haplotype analysis in study cohort.
Soma Saeed (5720657), Ishrat Mahjabeen (846545), Mahmood Akhtar Kayani (783301), Romana Sarwar (5720654), Kashif Bashir (5720651)   +4 more
core   +1 more source

The causal relationship between systemic lupus erythematosus and juvenile myoclonic epilepsy: A Mendelian randomization study and mediation analysis

Ibrain, Volume 11, Issue 1, Page 98-105, Spring 2025.
Mendelian randomization (MR) studies were conducted using the inverse‐variance weighted (IVW) method, MR‐Egger and weighted median on juvenile myoclonic epilepsy (JME), and systemic lupus erythematosus (SLE) data from the Integrative Epidemiology Unit (IEU) Open genome‐wide association study (GWAS) database and the International League Against Epilepsy
Sirui Chen, Ningning Zhang, Ruirui Zhang, Lan Zhang, Dadong Luo, Junqiang Li, Yaqing Liu, Yunan Wang, Xinyue Duan, Xin Tian, Tiancheng Wang   +10 more
wiley   +1 more source

Chromosome 9 ALS and FTD locus is probably derived from a single founder.

, 2012
We and others have recently reported an association between amyotrophic lateral sclerosis (ALS) and single nucleotide polymorphisms on chromosome 9p21 in several populations.
Shatunov, A., Rollinson, PS, DeJesus-Hernandez, M, Pentti J. Tienari, Boxer, A.L., Hardy, J, Laaksovirta, H., Morrison, Karen E., Hardy, J., Aleksey Shatunov, John C. van Swieten, Rademakers, R, Restagno, Gabriella, Boeve, B.F., Bryan J. Traynor, Rollinson, Pamela Sara, Karen E. Morrison, Al-Chalabi, A., Ian R. Mackenzie, Morris, Huw Rees, Traynor, BJ, Mariely DeJesus-Hernandez, Jesus-Hernandez, M., Mackenzie, I.R., Morrison, KE, Orrell, R.W., Pamela Sara Rollinson, Mackenzie, Ian R., Simón-Sánchez, J, Nalls, MA, van Swieten, J.C., Waite, Adrian, Javier Simón-Sánchez, Tienari, P.J., Boeve, Bradley F., Morrison, Karen, Nalls, Michael A., Restagno, G, Myllykangas, L, Boxer, Adam L., Waite, Adrian James, Ammar Al-Chalabi, Waite, A, Mora, G, Heutink, P, Boeve, BF, Traynor, Bryan J., Waite, A., Adam L. Boxer, Shatunov, Aleksey, Rosa Rademakers, DeJesus-Hernandez, Mariely, Mackenzie, IR, Nigel Williams, Pickering-Brown, S, Hannu Laaksovirta, Chiò, A, Schymick, J., Williams, N, Simón-Sánchez, Javier, Laaksovirta, Hannu, Mok, K, Laaksovirta, H, Adrian Waite, Shaw, Pamela J., Pickering-Brown, Stuart, Rademakers, Rosa, Heutink, Peter, Mok, K., van Swieten, JC, Tienari, PJ, Liisa Myllykangas, Peuralinna, T, Heutink, P., Rollinson, P.S., Morris, HR, Hardy, John, Schymick, J, Shatunov, A, John Hardy, Simon-Sanchez, J., Huw R. Morris, Gabriele Mora, Morris, H.R., Peuralinna, T., Rademakers, R., Morrison, K.E., Mora, G., Pickering-Brown, S., Peuralinna, Terhi, Chio', Adriano, Peter Heutink, Richard W. Orrell, Chio, A., Terhi Peuralinna, Morrison, Karen E.; id_orcid, Myllykangas, Liisa, Williams, Nigel, Bradley F. Boeve, Gabriella Restagno, Pamela J. Shaw, Orrell, RW, Traynor, B.J., Shatunov, Aleksey; id_orcid, Kin Mok, Nalls, M.A., Al-Chalabi, Ammar, Williams, N., Boxer, AL, Shaw, P.J., Myllykangas, L., Mok, Kin, Mora, Gabriele, Orrell, Richard W., Tienari, Pentti J., Adriano Chiò, Schymick, Jennifer, Morris, Huw R., Shaw, PJ, Williams, Nigel Melville, Al-Chalabi, A, Chiò, Adriano, Restagno, G., van Swieten, John C., Michael A. Nalls, Stuart Pickering-Brown, Jennifer Schymick   +126 more
core   +1 more source

Environmental Pesticide Exposure in the Etiology of Pediatric Brain Tumors and Leukemia: A Scoping Review of Epidemiological Studies

International Journal of Cancer, EarlyView.
ABSTRACT Pediatric cancer is a significant cause of morbidity and mortality in children. The etiologies of pediatric cancer are largely unknown, but environmental pesticide exposures are likely to contribute. Chronic low‐dose exposure to pesticide mixtures through drinking water is a growing concern in agricultural communities.
Grace N. VanDeSteeg, Alyssa R. Russum, Matthew R. Sandbulte, Eleanor G. Rogan, Martha G. Rhoades   +4 more
wiley   +1 more source

Evaluation and identification of powdery mildew-resistant genes in 137 wheat relatives

Frontiers in Genetics
Powdery mildew is one of the most severe diseases affecting wheat yield and quality and is caused by Blumeria graminis f. sp. tritici (Bgt). Host resistance is the preferred strategy to prevent this disease.
Jiaojiao Wang, Hongxing Xu, Yanmin Qie, Ran Han, Xiaohui Sun, Ya Zhao, Bei Xiao, Zejun Qian, Xiaomei Huang, Ruishan Liu, Jiadong Zhang, Cheng Liu, Yuli Jin, Pengtao Ma   +13 more
doaj   +1 more source