Results 11 to 20 of about 229,423 (345)
A cladistic analysis of phenotypic associations with haplotypes inferred from restriction endonuclease mapping and DNA sequence data. III. Cladogram estimation. [PDF]
Genetics, 1992 We previously developed a cladistic approach to identify subsets of haplotypes defined by restriction endonuclease mapping or DNA sequencing that are associated with significant phenotypic deviations.
Alan R. Templeton +2 more
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Features and applications of haplotypes in crop breeding
Communications Biology, 2021 Climate change with altered pest-disease dynamics and rising abiotic stresses threatens resource-constrained agricultural production systems worldwide.
J. Bhat +4 more
semanticscholar +1 more source
Mapping Haplotype-haplotype Interactions with Adaptive LASSO [PDF]
BMC Genetics, 2010 AbstractBackgroundThe genetic etiology of complex diseases in human has been commonly viewed as a complex process involving both genetic and environmental factors functioning in a complicated manner. Quite often the interactions among genetic variants play major roles in determining the susceptibility of an individual to a particular disease ...
Roberto Romero +3 more
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Detecting Local Haplotype Sharing and Haplotype Association [PDF]
Genetics, 2014 Abstract A novel haplotype association method is presented, and its power is demonstrated. Relying on a statistical model for linkage disequilibrium (LD), the method first infers ancestral haplotypes and their loadings at each marker for each individual.
Yongtao Guan, Hanli Xu, Hanli Xu
openaire +3 more sources
Plant Biotechnology Journal, 2020 Summary Haplotype‐based breeding, a recent promising breeding approach to develop tailor‐made crop varieties, deals with identification of superior haplotypes and their deployment in breeding programmes.
P. Sinha +10 more
semanticscholar +1 more source
Discovery of beneficial haplotypes for complex traits in maize landraces
Nature Communications, 2020 Genetic variation is of crucial importance for crop improvement. Landraces are valuable sources of diversity, but for quantitative traits efficient strategies for their targeted utilization are lacking.
M. Mayer +7 more
semanticscholar +1 more source
Massive haplotypes underlie ecotypic differentiation in sunflowers
Nature, 2019 Species often include multiple ecotypes that are adapted to different environments1. However, it is unclear how ecotypes arise and how their distinctive combinations of adaptive alleles are maintained despite hybridization with non-adapted populations2–4.
M. Todesco +23 more
semanticscholar +1 more source
Score tests for association between traits and haplotypes when linkage phase is ambiguous.
American Journal of Human Genetics, 2002 A key step toward the discovery of a gene related to a trait is the finding of an association between the trait and one or more haplotypes. Haplotype analyses can also provide critical information regarding the function of a gene; however, when unrelated
D. Schaid +4 more
semanticscholar +1 more source
Minimal haplotype tagging [PDF]
Proceedings of the National Academy of Sciences, 2003 The high frequency of single-nucleotide polymorphisms (SNPs) in the human genome presents an unparalleled opportunity to track down the genetic basis of common diseases. At the same time, the sheer number of SNPs also makes unfeasible genomewide disease association studies.
Isaac S. Kohane +5 more
openaire +4 more sources
Polymorphisms of MicroRNA-146a Gene in Behcet’s Disease in Iraqi Patients
Journal of Pure and Applied Microbiology, 2018 The present study was carried out to detect the association of miR-146a haplotypes polymorphisms with Behcet’s Disease in Iraqi patients, PCR-SSCP technique used in present study, blood was used to DNA extraction, the results show that there was strong
Israa Harjan Mohsen +4 more
doaj +1 more source