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Haplotype‐Association Analysis
2008Association methods based on linkage disequilibrium (LD) offer a promising approach for detecting genetic variations that are responsible for complex human diseases. Although methods based on individual single nucleotide polymorphisms (SNPs) may lead to significant findings, methods based on haplotypes comprising multiple SNPs on the same inherited ...
Nianjun, Liu, Kui, Zhang, Hongyu, Zhao
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Haplotyping as Perfect Phylogeny
2004We consider the following problem: Given n genotypes, does there exist a set H of haplotypes such that each genotype is generated by a pair from this set, and this det can be derived on a perfect phylogeny. Recently, Gusfield, 2002, presented a polynomial time algorithm to solve this problem that uses established results from matroid and graph theory ...
Bafna V. +3 more
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Direct determination of molecular haplotypes by chromosome microdissection
Nature Methods, 2010Yan Xiao, Qingwei Wang, Yue Feng
exaly