Results 211 to 220 of about 175,373 (307)

Macular telangiectasia type 2 genetic risk variants associated with clinical characteristics in the Slovenian cohort

Acta Ophthalmologica, EarlyView.
Abstract Purpose Early diagnosis of macular telangiectasia type 2 (MacTel) remains challenging, and the contribution of genetic variation to its clinical heterogeneity is unclear. This study investigated associations between MacTel risk variants and clinical characteristics in a Slovenian cohort.
Ajda Kunčič, Nataša Debeljak, Petra Hudler, Janez Smerkolj, Mojca Urbančič   +4 more
wiley   +1 more source

HLA Diversity of Over 500,000 Individuals on the DATRI Register Across 18 Regions in India. [PDF]

HLA
Agapiou M, Cereb N, Rutt C, Marsh SGE, Robinson J.   +4 more
europepmc   +1 more source

A genetic and historical perspective on the origins of keratitis fugax hereditaria

Acta Ophthalmologica, EarlyView.
Abstract Purpose To investigate the genetic and genealogical background of keratitis fugax hereditaria (KFH), a periodic corneal disease caused by the heterozygous pathogenic variant c.61G>C in the NLRP3 gene. KFH is characterized by recurrent unilateral autoinflammatory attacks alternating between the eyes and permanent corneal opacities.
Annamari T. Immonen, Sara P. Luostarinen, Päivi Lahermo, Sabita Kawan, Kati Donner, Joseph D. Terwilliger, Michael P. Backlund, Joni A. Turunen   +7 more
wiley   +1 more source

Ecological and Genomic Evidence of Cryptic Speciation in the Potato Psyllid (<i>Bactericera cockerelli</i>). [PDF]

Evol Appl
Kenney JR, Scarparo G, Molfini M, Tran M, Tran S, Murguia S, Gebiola M, Sarkar P, Purcell J, Mauck KE.   +9 more
europepmc   +1 more source

Genetic Engineering of Tumor‐Infiltrating Lymphocytes (TIL) via a T‐Editor Platform to Enhance Anti‐Tumor Activity

Cancer Science, EarlyView.
A rapid and efficient CRISPR‐mediated gene editing platform for TIL engineering identified FAM84B as a novel potential target to enhance antitumor activity and pioneered the use of CBE to generate FAM84B loss‐of‐function TIL with enhanced antitumor activity.
Fenge Li, Xuejiao Ma, Yongming Xue, Jilong Yang, Ruijing Wang, Xiang Li, Chao Zhang, Wenhan Lu, Mei Liu, Yue Xu, Xinyi Wang, Shengnan Wu, Ning Kang, Chunhua Ma   +13 more
wiley   +1 more source

Mitochondrial Phylogeography of the Proboscis Monkey (<i>Nasalis larvatus</i>) Reveals Riverine and Coastal Population Structure Across Eastern Borneo. [PDF]

Ecol Evol
Atmoko T, Putra WPB, Qiptiyah M, Prihatini I, Mukhlisi, Akbar MA, Yamada C, Ophinni Y.   +7 more
europepmc   +1 more source

Treatment‐Free Remission in Chronic Myeloid Leukemia: Toward Precision and Personalized Approaches to Functional Cure

Cancer Science, EarlyView.
Immune surveillance of residual leukemic stem cells after tyrosine kinase inhibitor discontinuation involves coordinated NK‐cell, CTL, Treg, pDC, and neutrophil activity that predicts treatment‐free remission, while exhausted CTLs and Treg expansion predict relapse in chronic myeloid leukemia.
Hiroshi Ureshino, Shinya Kimura
wiley   +1 more source

Haplotypes across the Oceans: worldwide phylogeography, evolution, conservation and nomenclature standardization in the leatherback sea turtle (Dermochelys coriacea). [PDF]

PLoS One
Colombo WD, Teodoro SSA, da Fonseca JLG, Schultz GL, Vargas SM.   +4 more
europepmc   +1 more source

Peanut‐Specific IgG4 mAbs Promote Regulatory Immune Responses Ex Vivo and Improve Oral Immunotherapy in Mice

Clinical &Experimental Allergy, EarlyView.
Allergen‐specific IgG4 mAbs were shown to block facilitated IgE binding to B cells and redirect allergens towards myeloid APC, leading to increased IL‐10 production in vitro. In combination with oral AIT, the mAbs inhibited mast cell activation and sustained allergen‐specific IgG4 levels in an in vivo model of peanut allergy. ABSTRACT Background Peanut
Pascal Gasser, Alex A. J. Overman, Mojtaba Porbahaie, Chiara Arena, Juliane Konrad, Renate Repke, Sandra Götschi, Dimitri Bieli, Tiziana Sonati, Alcide Barberis, Niccolò Pengo, R. J. Joost van Neerven, Natascha Wuillemin   +12 more
wiley   +1 more source