Results 21 to 30 of about 109,284 (237)

SNP-Density Crossover Maps of Polymorphic Transposable Elements and HLA Genes Within MHC Class I Haplotype Blocks and Junction

Frontiers in Genetics, 2021
The genomic region (~4 Mb) of the human major histocompatibility complex (MHC) on chromosome 6p21 is a prime model for the study and understanding of conserved polymorphic sequences (CPSs) and structural diversity of ancestral haplotypes (AHs)/conserved ...
Jerzy K. Kulski, Jerzy K. Kulski, Shingo Suzuki, Takashi Shiina   +3 more
doaj   +1 more source

Optimizing Sequencing Resources in Genotyped Livestock Populations Using Linear Programming

Frontiers in Genetics, 2021
Low-cost genome-wide single-nucleotide polymorphisms (SNPs) are routinely used in animal breeding programs. Compared to SNP arrays, the use of whole-genome sequence data generated by the next-generation sequencing technologies (NGS) has great potential ...
Hao Cheng, Keyu Xu, Jinghui Li, Kuruvilla Joseph Abraham, Kuruvilla Joseph Abraham   +4 more
doaj   +1 more source

Advances in methodologies for detecting MHC-B variability in chickens

Poultry Science, 2020
The chicken major histocompatibility B complex (MHC-B) region is of great interest owing to its very strong association with resistance to many diseases. Variation in the MHC-B was initially identified by hemagglutination of red blood cells with specific
J.E. Fulton
doaj   +1 more source

The mitochondrial DNA HVI and HVII sequences and haplogroup distribution in a population sample from Vietnam

Annals of Human Biology, 2022
Background Mitochondrial DNA (mtDNA) analysis has been used in forensics and requires well-established population databases for statistical interpretations. However, high-quality mtDNA data from Vietnamese population samples have been limited.
Nam Ngoc Nguyen, Trong Luc Hoang, Trang Hong Nguyen, Phuong Thi Le, Chi Hung Nguyen, Viet Vinh Tran, Hoang Ha Chu, Ha Hoang   +7 more
doaj   +1 more source

Discovery and Validation of Grain Shape Loci in U.S. Rice Germplasm Through Haplotype Characterization

Frontiers in Genetics, 2022
Rice grain shape is a major determinant of rice market value and the end-use. We mapped quantitative trait loci (QTL) for grain shape traits in a bi-parental recombinant inbred line population (Trenasse/Jupiter) and discovered two major grain length QTLs—
Brijesh Angira, Tommaso Cerioli, Adam N. Famoso   +2 more
doaj   +1 more source

Immune Checkpoint Inhibitor–Related Myositis and Associated Triad Overlap Syndrome

Arthritis Care &Research, EarlyView.
Objective Immune checkpoint inhibitor (ICI) myositis is a rare but a highly morbid condition, particularly with the ICI myositis triad syndrome of myositis, myocarditis, and myasthenia gravis. We report the clinical characteristics of ICI myositis and all‐cause mortality in these patients.
Selene Rubino, Grant W. Cannon, Brian C. Sauer, Jorge Rojas, Gregory J. Stoddard, Gary A. Kunkel, Jessica A. Walsh, Bryant R. England, Joshua F. Baker, Tawnie J. Braaten   +9 more
wiley   +1 more source

DNA barcoding of minor fish fauna: a case study in the Province of Bolzano/Bozen, Italy

The European Zoological Journal
The fish fauna of the Province of Bolzano/Bozen (northern Italy) currently includes at least 35 species, mostly defined on a morphological basis. Naturally occurring fish are presumably native to the northern Adriatic Catchment, as the alpine divide is ...
L. Zanovello, M. Morpurgo, H. Grund, S. Casari, T. Grossgasteiger, L. Schober, N. Stampfl, G. Oberhofer, R. Spechtenhauser, D. Eisendle, M. Girardi, A. Gandolfi   +11 more
doaj   +1 more source

alpha-thalassemia, HbS, and beta-globin gene cluster haplotypes in two Afro-Uruguayan sub-populations from northern and southern Uruguay

Genetics and Molecular Biology, 2006
Hemoglobinopathies are the most common monogenic disorders worldwide; however, they have never been systematically studied from a genetic perspective in Uruguay. In this study, we determined the frequencies of hemoglobin variants in Afro-Uruguayans.
Julio A. da Luz, Mónica Sans, Elza Miyuki Kimura, Dulcinéia Martins Albuquerque, Maria de Fatima Sonati, Fernando Ferreira Costa   +5 more
doaj   +1 more source

Stochastic Nanoscale Biophysical Cues as a Basis for the Induction of Glioblastoma‐Like Transcriptional Programs in Astrocytes

Advanced Science, EarlyView.
Stochastic nanoscale physical cues induce glioblastoma (GBM)‐associated transcriptional traits in naïve astrocytes leading to spontaneous formation of spheroids. Cells within spheroids express activated‐MMP2 and a differential gene expression pattern involving P53 and NOTCH3, providing evidence for a role for changes in brain topography, as observed in
Laurent Starck, Tobias Butelmann, Sabrina Hogan, Melika Sarem, Bernd Heimrich, Ritwick Sawarkar, Marie‐Françoise Ritz, Gregor Hutter, V. Prasad Shastri   +8 more
wiley   +1 more source

TOMM40 and APOC1 variants differentiate the impacts of the APOE ε4 allele on Alzheimer's disease risk across sexes, ages, and ancestries

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
INTRODUCTION The variability in apolipoprotein E (APOE) ε4‐attributed susceptibility to Alzheimer's disease (AD) across ancestries, sexes, and ages may stem from the modulating effects of other genetic variants.
Alexander M. Kulminski, Ethan Jain‐Washburn, Ian Philipp, Yury Loika, Elena Loiko, Irina Culminskaya   +5 more
doaj   +1 more source