Results 21 to 30 of about 149 (149)

S haplotype collection in Brassicaceae crops-an updated list of S haplotypes.

Breeding science, 2023
Self-incompatibility is the system that inhibits pollen germination and pollen tube growth by self-pollen. This trait is important for the breeding of Brassica and Raphanus species. In these species, self-incompatibility is governed by the S locus, which contains three linked genes (a set called the S haplotype), i.e., S-locus receptor kinase, S-locus ...
Yamamoto, Masaya, Ishii, Tomoko, Ogura, Marina, Akanuma, Takashi, Zhu, Xing-Yu, Kitashiba, Hiroyasu   +5 more
openaire   +2 more sources

High-throughput haplotype determination over long distances by haplotype fusion PCR and ligation haplotyping [PDF]

Nature Protocols, 2009
When combined with haplotype fusion PCR (HF-PCR), ligation haplotyping is a robust, high-throughput method for empirical determination of haplotypes, which can be applied to assaying both sequence and structural variation over long distances. Unlike alternative approaches to haplotype determination, such as allele-specific PCR and long PCR, HF-PCR and ...
Daniel J. Turner, Matthew E. Hurles
openaire   +3 more sources

Shennong 1 Chicken 40K Liquid Chip: Advancing Genetic Research in Chinese Indigenous Chickens

Animal Research and One Health, EarlyView.
Based on comprehensive genomic data of Chinese indigenous chickens, we developed a specialized genotyping array for this population. Comparative analyses with published mainstream arrays and evaluations, including genetic assessment of diverse chicken types and gene mining analyses, demonstrated its superior applicability to Chinese indigenous chickens.
Chaoqun Gao, Chenxi Zhang, Kaiyuan Tian, Shucan Zhao, Yongle Xue, Sensen Yan, Chengpeng Xiao, Donghua Li, Guirong Sun, Ruili Han, Ruirui Jiang, Yadong Tian, Wenting Li, Kejun Wang, Xiangtao Kang   +14 more
wiley   +1 more source

Improved Prediction of CYP2D6 Catalyzed Drug Metabolism by Taking Variant Substrate Specificities and Novel Polymorphic Haplotypes into Account

Clinical Pharmacology &Therapeutics, EarlyView.
The polymorphic CYP2D6 enzyme plays a pivotal role in the metabolism of approximately 25% of clinically prescribed drugs. However, the impact of specific genetic variants on the interindividual variability in CYP2D6‐mediated drug metabolism remains insufficiently quantified. This translational study sought to address this gap by analyzing the genotypes
Inger Johansson, Emmanouella M. Xanthopoulou, Yitian Zhou, Anabel Sanchez‐Spitman, Maaike van der Lee, Birgit M. Wollmann, Elisabet Størset, Jesse J. Swen, Henk‐Jan Guchelaar, Espen Molden, Marin M. Jukic, Magnus Ingelman‐Sundberg   +11 more
wiley   +1 more source

A Random Forests Framework for Modeling Haplotypes as Mosaics of Reference Haplotypes

Frontiers in Genetics, 2019
Many genomic data analyses such as phasing, genotype imputation, or local ancestry inference share a common core task: matching pairs of haplotypes at any position along the chromosome, thereby inferring a target haplotype as a succession of pieces from reference haplotypes, commonly called a mosaic of reference haplotypes.
Faux, Pierre, Geurts, Pierre, Druet, Tom
openaire   +6 more sources

Implementing Pre‐Emptive Pharmacogenetics: Impact of Early Pharmacogenetic Screening in a Pediatric Oncology Cohort of 1,151 Subjects

Clinical Pharmacology &Therapeutics, EarlyView.
In pediatric oncology, pharmacogenetic guidelines are underutilized and the potential impact of pre‐emptive pharmacogenetic screening remains largely unexplored despite this field's need for individualized approaches. While comprehensive pharmacogenetic guidelines are not yet available for all anticancer drugs, evidence‐based recommendations exist for ...
Emma C. Bernsen, Eugène T.P. Verwiel, Maaike van der Lee, Jesse J. Swen, Marcel Santoso, Leiah J. Brigitha, Rick Admiraal, Bastiaan B.J. Tops, Alwin D.R. Huitema, Patrick Kemmeren, Jayne Y. Hehir‐Kwa, Lidwien M. Hanff, Meta H.M. Diekstra   +12 more
wiley   +1 more source

Haplotypes versus Genotypes on Pedigrees [PDF]

Algorithms for Molecular Biology, 2010
Genome sequencing will soon produce haplotype data for individuals. For pedigrees of related individuals, sequencing appears to be an attractive alternative to genotyping. However, methods for pedigree analysis with haplotype data have not yet been developed, and the computational complexity of such problems has been an open question.
Bonnie Kirkpatrick, Bonnie Kirkpatrick
openaire   +7 more sources

Prevalence of Actionable Pharmacogenetic Genotype Frequencies, Cautionary Medication Use, and Polypharmacy in Community‐Dwelling Older Adults

Clinical Pharmacology &Therapeutics, EarlyView.
Older adults (65 years and over) frequently manage complex medication regimens and are vulnerable to adverse drug reactions and treatment inefficacies, some of which could be preventable with pharmacogenetics (PGx)‐guided prescribing. This study examined the prevalence of actionable PGx genotypes (i.e., those linked to a guideline that recommends a ...
Chad A. Bousman, Ankita Narang, Ziad Al Bkhetan, Robyn L. Woods, Suzanne G. Orchard, Alice J. Owen, Michelle A. Fravel, Julia Gilmartin‐Thomas, Joanne Ryan, Peter D. Fransquet, Rory Wolfe, Chenglong Yu, John J. McNeil, Paul Lacaze, Michael E. Ernst   +14 more
wiley   +1 more source

From One Strand Dyed/Undyed Hair With/Without Root to Fast and Successful STR Profiling and Evaluation With Principle Component Analysis

ELECTROPHORESIS, EarlyView.
ABSTRACT Fallen/shed single hair shafts with/without roots can be encountered as evidence in crime scenes. Identification from hair exhibits serious difficulties, due to the low amount of DNA, PCR inhibitors, and the existence of DNA mostly in degraded forms. Exposure of hair to chemical oxidation, sunlight, etc.
Gulten Rayimoglu, Fatma Cavus Yonar, Beril Anılanmert   +2 more
wiley   +1 more source

Bitter Taste Receptor Agonists Induce Apoptosis in Papillary Thyroid Cancer

Head &Neck, EarlyView.
ABSTRACT Background Papillary thyroid carcinoma (PTC) is the most common thyroid malignancy, with a 20% recurrence rate. Bitter taste receptors (T2Rs) and their genes (TAS2Rs) may regulate survival in solid tumors. This study examined T2R expression and function in PTC cells.
Kimberly Wei, Brianna L. Hill, Joel C. Thompson, Zoey A. Miller, Arielle Mueller, Robert J. Lee, Ryan M. Carey   +6 more
wiley   +1 more source