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Conjugation of Haptens

2008
Many naturally occurring proteins, peptides, carbohydrates, nucleic acids, and lipids, as well as synthetic peptides, are successful immunogens. To elicit an immune response, a compound must contain an antigenic determinant or epitope and must be of sufficient size to initiate lymphocyte activation necessary for an antibody response. In practice, small
Ranulfo, Lemus, Meryl H, Karol
openaire   +2 more sources

Synthesis of Haptens and Conjugates for ELISA of Glycitein: Development and Validation of an Immunological Test

open access: yesJournal of Agricultural and Food Chemistry, 2008
International audienceTwo carboxylic acid haptens of glycitein were synthesized, with a spacer arm at the C2 position. They differed in the length of the spacer arm, with the length of the spacer arms being three or four carbon atoms, and were named ...
Patrick Sauvant   +2 more
exaly   +2 more sources

Synthesis of corticosteroid haptens

Steroids, 1974
Abstract 6α- and 6β-Hemisuccinoxy derivatives of cortisol, 11-desoxycortisol, 21-desoxycortisol and 21-desoxycortisone were synthesized. The intermediate 6-hydroxy derivatives were prepared by the auto-oxidation of 3,5-dienol 3-alkyl ethers. During this step the dihydroxyacetone side-chain of cortisol and 11-desoxycortisol was protected by the 17,21 ...
A, Tsuji   +3 more
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The Hapten-Atopy hypothesis II: the 'cutaneous hapten paradox'.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2011
One explanation for the striking increase in atopic disease in developed countries over the last 50 years has been the 'Hygiene Hypothesis'; a reduced exposure to pathogenic microorganisms. We have postulated previously that oral and cutaneous exposure to chemicals generally and to haptens in particular, may have also contributed to the increased ...
McFadden, J. P.   +4 more
openaire   +3 more sources

Evaluation of Rh hapten

American Journal of Obstetrics and Gynecology, 1956
Abstract In this paper, we have detailed the current methods of Rh hapten production and have described its administration to the sensitized Rh-negative woman. Five representative case histories have been presented along with results obtained in the first 135 cases treated.
B B, CARTER   +3 more
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Searching Haptens, Carrier Proteins, and Anti-Hapten Antibodies

2007
Haptens are small molecules that are usually nonimmunogenic unless coupled to some carrier proteins. The generation of anti-hapten antibodies is important for the development of immunodiagnostics and therapeutics. Recently, our group has developed a database called HaptenDB, which provides comprehensive information about 1,087 haptens. In this chapter,
Shilpy, Srivastava   +3 more
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Stimulation of anti‐hapten response by heterologous protein devoid of hapten

European Journal of Immunology, 1972
AbstractRabbits were immunized with dinitrophenylated proteins. Injections with heterologous proteins were given 11 to 25 days after the primary injection. Spleen cell suspensions from the immunized animals were exposed to either (a) the original antigen, (b) the carrier protein of the original antigen (c) the heterologous protein used for the second ...
M, Bustin   +4 more
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