Results 171 to 180 of about 8,472 (222)
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2008
Many naturally occurring proteins, peptides, carbohydrates, nucleic acids, and lipids, as well as synthetic peptides, are successful immunogens. To elicit an immune response, a compound must contain an antigenic determinant or epitope and must be of sufficient size to initiate lymphocyte activation necessary for an antibody response. In practice, small
Ranulfo, Lemus, Meryl H, Karol
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Many naturally occurring proteins, peptides, carbohydrates, nucleic acids, and lipids, as well as synthetic peptides, are successful immunogens. To elicit an immune response, a compound must contain an antigenic determinant or epitope and must be of sufficient size to initiate lymphocyte activation necessary for an antibody response. In practice, small
Ranulfo, Lemus, Meryl H, Karol
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European Journal of Organic Chemistry, 2002 The synthesis of the first two haptens designed to elicit catalytic hydrolytic antibodies for the dynamic kinetic resolution of racemic 4-substituted 4H-oxazolin-5-ones is reported.
Véronique Gouverneur
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The Hapten-Atopy hypothesis II: the 'cutaneous hapten paradox'.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2011One explanation for the striking increase in atopic disease in developed countries over the last 50 years has been the 'Hygiene Hypothesis'; a reduced exposure to pathogenic microorganisms. We have postulated previously that oral and cutaneous exposure to chemicals generally and to haptens in particular, may have also contributed to the increased ...
McFadden, J. P. +4 more
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Synthesis of corticosteroid haptens
Steroids, 1974Abstract 6α- and 6β-Hemisuccinoxy derivatives of cortisol, 11-desoxycortisol, 21-desoxycortisol and 21-desoxycortisone were synthesized. The intermediate 6-hydroxy derivatives were prepared by the auto-oxidation of 3,5-dienol 3-alkyl ethers. During this step the dihydroxyacetone side-chain of cortisol and 11-desoxycortisol was protected by the 17,21 ...
A, Tsuji +3 more
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American Journal of Obstetrics and Gynecology, 1956
Abstract In this paper, we have detailed the current methods of Rh hapten production and have described its administration to the sensitized Rh-negative woman. Five representative case histories have been presented along with results obtained in the first 135 cases treated.
B B, CARTER +3 more
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Abstract In this paper, we have detailed the current methods of Rh hapten production and have described its administration to the sensitized Rh-negative woman. Five representative case histories have been presented along with results obtained in the first 135 cases treated.
B B, CARTER +3 more
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Stimulation of anti‐hapten response by heterologous protein devoid of hapten
European Journal of Immunology, 1972AbstractRabbits were immunized with dinitrophenylated proteins. Injections with heterologous proteins were given 11 to 25 days after the primary injection. Spleen cell suspensions from the immunized animals were exposed to either (a) the original antigen, (b) the carrier protein of the original antigen (c) the heterologous protein used for the second ...
M, Bustin +4 more
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Searching Haptens, Carrier Proteins, and Anti-Hapten Antibodies
2007Haptens are small molecules that are usually nonimmunogenic unless coupled to some carrier proteins. The generation of anti-hapten antibodies is important for the development of immunodiagnostics and therapeutics. Recently, our group has developed a database called HaptenDB, which provides comprehensive information about 1,087 haptens. In this chapter,
Shilpy, Srivastava +3 more
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Effects of charged groups in haptens on adsorption equilibrium of hapten antibody
Biotechnology and Bioengineering, 1988AbstractAntisera against charged (p‐azobenzoate and p‐azoben zenesulfonate) and uncharged (dinitrophenyl) haptenic groups were produced in rabbits, and the equilibrium characteristics of hapten‐antibody were measured by use of immunoadsorbents. The antibody to the uncharged hapten formed a stable binding with the hapten to the changes in ionic strength
E, Sada +4 more
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Inhibition by Hapten of Cellular Immune Responses to a Hapten–Protein Conjugate
Nature, 1970STIMULATION of specific immunocompetent cells by antigen has been postulated to involve an interaction of antigen with a complementary cell surface receptor. Furthermore, the specificity of these receptors, although not precisely established, may be very similar to that of serum-type antibody1–3.
T C, Francis, W E, Paul
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