Results 41 to 50 of about 35,609 (207)

Turning Unpredictable Biomolecule Adsorption to Controlled Corona Formation: Focus on Carbon Nanomaterials

Advanced Materials, EarlyView.
Controlling the protein corona formation onto carbon nanomaterials (CNMs) enhances their functionalities as platforms for cancer theranostics. Here, we reviewed the effects of the intrinsic and acquired properties of CNMs on protein corona formation, the consequent biological and toxicological outcomes, and the strategies to reshape corona formation ...
Yajuan Zou, Yalei Hu, Jie Yu, Naoki Komatsu, Yuta Nishina, Alberto Bianco   +5 more
wiley   +1 more source

Dual Blockade of LILRB1 and LILRB2 Enhances Antiviral Immune Responses in SIV Infection

Advanced Science, EarlyView.
Dual LILRB1/B2 blockade with mac20G10 reshapes myeloid activation during acute SIV infection by targeting LILRB1 and LILRB2 on myeloid cells. This treatment enhances CD80 expression on selected myeloid subsets and increases plasma IFN‐λ, IL‐8, and IL‐1RA.
Florian Meurisse, Sixtine Coindre, Anne Wijkhuisen, Romain Marlin, Laure Fournier Le Ray, Juliette Pons, Melyssa Yaugel‐Novoa, Véronique Avettand‐Fenoel, Laurent Abi‐Rached, Anne‐Sophie Gallouet, Francis Relouzat, Mael Gourves, Asier Saez‐Cirion, Hisashi Arase, Gerard Zurawski, Sandra Zurawski, Nathalie Dereuddre‐Bosquet, Roger Le Grand, Stéphanie Simon, Olivier Lambotte, Benoit Favier   +20 more
wiley   +1 more source

Haptoglobin levels are associated with haptoglobin genotype and a+-thalassaemia in a malaria-endemic area [PDF]

, 2006
Haptoglobin (Hp) is an acute phase protein that removes free hemoglobin (Hb) released during hemolysis. Hp has also been shown to be toxic for malaria parasites. a+-Thalassemia is a hemoglobinopathy that results in subclinical hemolytic anemia.
Imrie, H, Piper, KP, Hume, JC, Hume, JCC, Tavul, L, Fowkes, FJ, Piper, Karen, Fowkes, FJI, Michon, P, Reeder, JC, Day, KP   +10 more
core  

Haptoglobin as a supplement in in vitro embryo culture: a tool for improving bovine embryo development and quality

Biological Research
Background Recent studies have indicated the potential involvement of haptoglobin in a variety of events during mammalian reproduction, with previous research highlighting its efficacy in promoting porcine embryo development.
Karina Cañón-Beltrán, Yulia N. Cajas, Cristina Martínez-López, Carla Moros-Nicolás, Pilar Sòria-Monzó, Miriam Balastegui-Alarcón, Manuel Avilés, Dimitrios Rizos, Francisco A. García-Vázquez, Mª José Izquierdo-Rico   +9 more
doaj   +1 more source

Haptoglobin Regulates Macrophage/Microglia‐Induced Inflammation and Prevents Ischemic Brain Damage Via Binding to HMGB1

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background HMGB1 (high‐mobility group box 1) is known to worsen the functional prognosis after cerebral ischemia. Hp (haptoglobin) binds and sequesters HMGB1.
Mayuka Morimoto, Takafumi Nakano, Saki Egashira, Keiichi Irie, Kiyoshi Matsuyama, Momoka Wada, Yoshihiko Nakamura, Yutaka Shigemori, Hiroyasu Ishikura, Yuta Yamashita, Kazuhide Hayakawa, Kazunori Sano, Kenichi Mishima   +12 more
doaj   +1 more source

High Proportion of PNH Type II Neutrophils Is Associated With Thrombosis in Patients Displaying a PNH Clone ≥ 1%

American Journal of Hematology, EarlyView.
ABSTRACT The clinical significance of PNH Type II white blood cells (WBCs) remains unclear. We assessed the relative percentage (rel%) of Type II neutrophils in 355 patients with a PNH clone ≥ 1% on neutrophils enrolled by 33 flow cytometry laboratories in the 5‐year French nation‐wide multicenter prospective observational study.
Orianne Wagner‐Ballon, Anne‐Catherine Lhoumeau, Anna Raimbault, Camille Debord, Jean‐Philippe Vial, Valérie Soenen, Mélanie Pannetier, Edouard Bonneville, Elsa Bera, Caroline Bret, Nicolas Chapuis, Véronique Latger‐Cannard, Caroline Mayeur‐Rousse, Véronique Harrivel, François Vergez, Marie Loosveld, Juliette Vo Xuan, Stéphanie Mathis, Gérard Socié, Flore Sicre de Fontbrune, Régis Peffault de Latour, Bernard Drenou, Agathe Debliquis, Magali Le Garff‐Tavernier, on behalf of the French PNH working group CytHem‐HPN, Thomas Boyer, Mikaël Roussel, Marie Guillon, Sabrina Bouyer, Isabelle Kittler, Franck Geneviève, Julien Guy, Sophie Brun, Claude Capron, Sébastien Lachot, Francine Garnache‐Ottou, Richard Veyrat‐Masson, Corine Brunet, Caren Brumpt, Ludovic Lhermitte. Finally, Louis Terriou, Nicolas Blin   +41 more
wiley   +1 more source

Haptoglobin buffers lipopolysaccharides to delay activation of NFκB

Frontiers in Immunology
It has remained yet unclear which soluble factors regulate the anti-inflammatory macrophage phenotype observed in both homeostasis and tumourigenesis. We show here that haptoglobin, a major serum protein with elusive immunoregulatory properties, binds ...
Laura Zein, Laura Zein, Josina Grossmann, Josina Grossmann, Helena Swoboda, Helena Swoboda, Christina Borgel, Christina Borgel, Bernhard Wilke, Bernhard Wilke, Stephan Awe, Andrea Nist, Thorsten Stiewe, Oliver Stehling, Oliver Stehling, Sven-Andreas Freibert, Sven-Andreas Freibert, Till Adhikary, Till Adhikary, Ho-Ryun Chung   +19 more
doaj   +1 more source

Haptoglobin inhibits phospholipid transfer protein activity in hyperlipidemic human plasma

Lipids in Health and Disease, 2009
Background Haptoglobin is a plasma protein that scavenges haemoglobin during haemolysis. Phospholipid Transfer Protein (PLTP) transfers lipids from Low Density Lipoproteins (LDL) to High Density Lipoproteins (HDL). PLTP is involved in the pathogenesis of
Leon Carlos G, Wasan Kishor M, Henderson Ryan J   +2 more
doaj   +1 more source

Diagnostic accuracy of Wisconsin and California scoring systems to detect bovine respiratory disease in preweaning dairy calves under subtropical environmental conditions

Journal of Dairy Science, 2022
: Bovine respiratory disease (BRD) is a multifactorial disease which causes short- and long-term negative effects. Early detection is crucial for a prompt response to therapy, as well as to decrease mortality risk.
Nathalia Decaris, Sébastien Buczinski, Daniela Irlanda Castro Tárdon, Luana Camargo, Natali Regina Schllemer, Stefano Carlo Filippo Hagen, Amelia R. Woolums, Viviani Gomes   +7 more
doaj   +1 more source

Multivariate Analysis of Hematological Stress Biomarkers and Welfare Domains in Organic and Intensive Pig Farming in Italy: A Pilot Study

Animal Research and One Health, EarlyView.
Intensive or organic farming systems may expose pigs to management or environmental challenges. Our preliminary results concluded that organic farming might enhance adaptive immune function, showing that improvements in welfare can translate into measurable immunological benefits, based on the correlation between welfare assessment and physiological ...
Dorotea Ippolito, Talal Hassan, Antonio Marco Maisano, Stefania Bergagna, Cecilia Guasco, Barbara Miniscalco, Martina Tarantola, Elena Colombino, Claudio Caruso, Ahsan Muhammad, Silvia Mioletti, Laura Tomassone, Massimiliano Tursi, Cristina Vercelli, Giovanni Loris Alborali, Maria Teresa Capucchio   +15 more
wiley   +1 more source