Results 41 to 50 of about 38,975 (198)

Haptoglobin as a supplement in in vitro embryo culture: a tool for improving bovine embryo development and quality

Biological Research
Background Recent studies have indicated the potential involvement of haptoglobin in a variety of events during mammalian reproduction, with previous research highlighting its efficacy in promoting porcine embryo development.
Karina Cañón-Beltrán, Yulia N. Cajas, Cristina Martínez-López, Carla Moros-Nicolás, Pilar Sòria-Monzó, Miriam Balastegui-Alarcón, Manuel Avilés, Dimitrios Rizos, Francisco A. García-Vázquez, Mª José Izquierdo-Rico   +9 more
doaj   +1 more source

Haptoglobin gene polymorphisms and interleukin-6 and -8 levels in patients with sickle cell anemia

Revista Brasileira de Hematologia e Hemoterapia, 2015
BACKGROUND: Haptoglobin genotypes, and interleukin-6 and -8 participate in the pathophysiology of sickle cell anemia. The expression of cytokines is regulated by genetic mechanisms however the effect of haptoglobin polymorphisms on these cytokines is not
Bruna Spinella Pierrot-Gallo, Perla Vicari, Sandra Satiko Matsuda, Samuel Ademola Adegoke, Grazielle Mecabo, Maria Stella Figueiredo   +5 more
doaj   +1 more source

Quantification of Intact O-Glycopeptides on Haptoglobin in Sera of Patients With Hepatocellular Carcinoma and Liver Cirrhosis

Frontiers in Chemistry, 2021
Haptoglobin (Hp) is one of the acute-phase response proteins secreted by the liver, and its aberrant N-glycosylation was previously reported in hepatocellular carcinoma (HCC). Limited studies on Hp O-glycosylation have been previously reported.
Hong Shu, Hong Shu, Lei Zhang, Yiwei Chen, Yijie Guo, Limin Li, Fanghua Chen, Zhao Cao, Guoquan Yan, Chunlai Lu, Chao Liu, Shu Zhang   +11 more
doaj   +1 more source

Haptoglobin buffers lipopolysaccharides to delay activation of NFκB

Frontiers in Immunology
It has remained yet unclear which soluble factors regulate the anti-inflammatory macrophage phenotype observed in both homeostasis and tumourigenesis. We show here that haptoglobin, a major serum protein with elusive immunoregulatory properties, binds ...
Laura Zein, Laura Zein, Josina Grossmann, Josina Grossmann, Helena Swoboda, Helena Swoboda, Christina Borgel, Christina Borgel, Bernhard Wilke, Bernhard Wilke, Stephan Awe, Andrea Nist, Thorsten Stiewe, Oliver Stehling, Oliver Stehling, Sven-Andreas Freibert, Sven-Andreas Freibert, Till Adhikary, Till Adhikary, Ho-Ryun Chung   +19 more
doaj   +1 more source

Multivariate Analysis of Hematological Stress Biomarkers and Welfare Domains in Organic and Intensive Pig Farming in Italy: A Pilot Study

Animal Research and One Health, EarlyView.
Intensive or organic farming systems may expose pigs to management or environmental challenges. Our preliminary results concluded that organic farming might enhance adaptive immune function, showing that improvements in welfare can translate into measurable immunological benefits, based on the correlation between welfare assessment and physiological ...
Dorotea Ippolito, Talal Hassan, Antonio Marco Maisano, Stefania Bergagna, Cecilia Guasco, Barbara Miniscalco, Martina Tarantola, Elena Colombino, Claudio Caruso, Ahsan Muhammad, Silvia Mioletti, Laura Tomassone, Massimiliano Tursi, Cristina Vercelli, Giovanni Loris Alborali, Maria Teresa Capucchio   +15 more
wiley   +1 more source

Haptoglobin inhibits phospholipid transfer protein activity in hyperlipidemic human plasma

Lipids in Health and Disease, 2009
Background Haptoglobin is a plasma protein that scavenges haemoglobin during haemolysis. Phospholipid Transfer Protein (PLTP) transfers lipids from Low Density Lipoproteins (LDL) to High Density Lipoproteins (HDL). PLTP is involved in the pathogenesis of
Leon Carlos G, Wasan Kishor M, Henderson Ryan J   +2 more
doaj   +1 more source

Haptoglobin Regulates Macrophage/Microglia‐Induced Inflammation and Prevents Ischemic Brain Damage Via Binding to HMGB1

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background HMGB1 (high‐mobility group box 1) is known to worsen the functional prognosis after cerebral ischemia. Hp (haptoglobin) binds and sequesters HMGB1.
Mayuka Morimoto, Takafumi Nakano, Saki Egashira, Keiichi Irie, Kiyoshi Matsuyama, Momoka Wada, Yoshihiko Nakamura, Yutaka Shigemori, Hiroyasu Ishikura, Yuta Yamashita, Kazuhide Hayakawa, Kazunori Sano, Kenichi Mishima   +12 more
doaj   +1 more source

Indole‐3‐Acetic Acid Protects Bovine Hepatocytes Against Palmitic Acid‐Induced Lipid Accumulation and ER Stress Through SIRT3

Animal Research and One Health, EarlyView.
Cows with ketosis during the perinatal period often experience damage to the liver, a core metabolic organ, thereby exacerbating the disease's inherent vicious cycle. This study indicates that serum 3‐IAA concentrations were reduced in ketotic cows and show a significant negative correlation with hepatic TG content.
Dandan Qi, Chenchen Zhao, Guiying Li, Jinxia Li, Menglin Liu, Fanrong Kong, Enzhu Li, Jie Gao, Wenqi Liao, Akos Kenez, Wenwen Gao, Yuxiang Song, Xiliang Du, Guowen Liu, Xinwei Li, Lin Lei   +15 more
wiley   +1 more source

Diagnostic accuracy of Wisconsin and California scoring systems to detect bovine respiratory disease in preweaning dairy calves under subtropical environmental conditions

Journal of Dairy Science, 2022
: Bovine respiratory disease (BRD) is a multifactorial disease which causes short- and long-term negative effects. Early detection is crucial for a prompt response to therapy, as well as to decrease mortality risk.
Nathalia Decaris, Sébastien Buczinski, Daniela Irlanda Castro Tárdon, Luana Camargo, Natali Regina Schllemer, Stefano Carlo Filippo Hagen, Amelia R. Woolums, Viviani Gomes   +7 more
doaj   +1 more source

Nerve Growth Factor is Sufficient to Cause Multiple Osteoarthritis‐Relevant Pathologic Features in Naïve Murine Knee Joints

Arthritis &Rheumatology, EarlyView.
Objective Nerve growth factor (NGF), a key mediator of pain, is increased in osteoarthritic (OA) joints. Antibodies against NGF show analgesic effects in painful knee OA, but clinical development was stopped because of side effects in the joints. Knowledge about the biologic effects of NGF on joint tissues is limited. Therefore, we explored the effects
Alia M. Obeidat, Michael D. Newton, Jun Li, Baofeng Hu, Shingo Ishihara, Lindsey Lammlin, Lucas M. Junginger, Easton C. Farrell, Lai Wang, Frank C. Ko, Richard J. Miller, Carla R. Scanzello, Tristan Maerz, Rachel E. Miller, Anne‐Marie Malfait   +14 more
wiley   +1 more source