Results 51 to 60 of about 35,609 (207)

Indole‐3‐Acetic Acid Protects Bovine Hepatocytes Against Palmitic Acid‐Induced Lipid Accumulation and ER Stress Through SIRT3

open access: yesAnimal Research and One Health, EarlyView.
Cows with ketosis during the perinatal period often experience damage to the liver, a core metabolic organ, thereby exacerbating the disease's inherent vicious cycle. This study indicates that serum 3‐IAA concentrations were reduced in ketotic cows and show a significant negative correlation with hepatic TG content.
Dandan Qi   +15 more
wiley   +1 more source

Measuring lymphocyte kinetics in tropical field settings. [PDF]

open access: yes, 2005
Studies involving in-vivo labelling of lymphocyte DNA with 6,6-2H2-glucose to track T-cell turnover have contributed to understanding lymphocyte homeostasis in health and disease.
Griffin, George E   +5 more
core   +1 more source

A Multifaceted Interplay Among Hemophagocytosis, Interleukin‐18, and Type I Interferon Distinguishes Still Disease From Other Autoinflammatory Diseases

open access: yesArthritis &Rheumatology, EarlyView.
Objective The unknown pathophysiology and the lack of specific features for systemic juvenile idiopathic arthritis and adult‐onset Still disease (collectively known as Still disease; SD) delay diagnosis and appropriate treatment. The goal of this study was to identify features and mechanisms that distinguish SD from other systemic autoinflammatory ...
Yvonne M. Mueller   +16 more
wiley   +1 more source

Nerve Growth Factor is Sufficient to Cause Multiple Osteoarthritis‐Relevant Pathologic Features in Naïve Murine Knee Joints

open access: yesArthritis &Rheumatology, EarlyView.
Objective Nerve growth factor (NGF), a key mediator of pain, is increased in osteoarthritic (OA) joints. Antibodies against NGF show analgesic effects in painful knee OA, but clinical development was stopped because of side effects in the joints. Knowledge about the biologic effects of NGF on joint tissues is limited. Therefore, we explored the effects
Alia M. Obeidat   +14 more
wiley   +1 more source

Haptoglobin genotype is a risk factor for coronary artery disease in prediabetes: A case-control study

open access: yesAmerican Journal of Preventive Cardiology
Objective: Coronary artery disease (CAD) prediction remains inconsistent with many unappreciated risk factors. Haptoglobin genotype determines the haptoglobin protein's effectiveness to bind free hemoglobin and prevent oxidative stress, a contributor to ...
Emily Kate Mewborn   +5 more
doaj   +1 more source

Hemopexin Purification From Human Cohn Fraction IV Paste and Its Biophysical Characterization and Functional Evaluation in Sickle Cell Disease Mice

open access: yesBiotechnology and Bioengineering, EarlyView.
ABSTRACT Hemopexin (Hpx) is an acute phase plasma protein that is responsible for sequestration and removal of cell‐free heme with very high affinity (Kd < 1 pM). Hpx expression in liver cells is induced following an inflammatory event such as severe hemolysis. Therefore, plasma Hpx has potential clinical relevance due to its' ability to bind free heme,
Shuwei Lu   +8 more
wiley   +1 more source

Venous blood lactate concentration as a predictor of intestinal viability in horses with acquired indirect inguinal hernia

open access: yesEquine Veterinary Journal, EarlyView.
Abstract Background Acquired indirect inguinal hernia represents a life‐threatening emergency. Therapeutic decision‐making largely depends on intestinal viability, for which specific predictive parameters (such as venous lactate) have not been evaluated.
Raquel Rivero‐García   +8 more
wiley   +1 more source

Inflammation and neurodegeneration: identification of the acute phase protein haptoglobin as a potential modulator of apolipoprotein E-mediated regulation of brain cholesterol and beta-amyloid homeostasis [PDF]

open access: yes, 2009
State of the art: Alterations in cholesterol metabolism play a role in the pathogenesis of neurodegenerative diseases. Apolipoprotein E, the main lipid carrier in the brain, is a risk factor for Alzheimer’s disease.
CIGLIANO, LUISA
core  

Haptoglobin and the inflammatory and oxidative status in experimental diabetic rats: antioxidant role of haptoglobin [PDF]

open access: yes, 2013
Haptoglobin is a hemoglobin-binding acute-phase protein which possesses anti-inflammatory and antioxidative properties. In this study, we investigated changes in protein expression of rat haptoglobin under diabetes-related inflammatory and oxidative ...
Uskoković, Aleksandra   +6 more
core   +3 more sources

HIgher concentration of haptoglogin indicates transient inflammation and negative energy balance in transition cows [PDF]

open access: yesJournal of Veterinary and Animal Sciences, 2020
Haptoglobin is an acute phase protein that is of diagnostic significance in dairy cattle. In the present study, haptoglobin level was assessed during the periparturient period in 15 clinically healthy pregnant cows.
S.V. Vasudhar Bhat   +4 more
doaj  

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