Results 71 to 80 of about 41,191 (221)

Expert Consensus on the Diagnosis and Monitoring of Paroxysmal Nocturnal Hemoglobinuria (PNH): An Algorithmic Approach in an Era of New Treatments

European Journal of Haematology, EarlyView.
ABSTRACT Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hematologic disorder caused by a defect of glycosylphosphatidyl‐anchored proteins, leading to an uncontrolled complement‐mediated hemolysis. The advent of complement inhibitors in clinical practice radically changed patients' outcomes and survival.
Bruno Fattizzo, Monia Marchetti, Elisa Cannizzo, Arianna Gatti, Massimo Geuna, Anna Paola Iori, Maddalena Raia, Simona Sica, Francesco Buccisano   +8 more
wiley   +1 more source

Haptoglobin Genotypes in Nasopharyngeal Carcinoma

The International Journal of Biological Markers, 2009
Aim Haptoglobin polymorphisms are associated with different cancers; however, the occurrence of nasopharyngeal carcinoma (NPC) in relation to haptoglobin polymorphisms has not been reported.
Ching-Chih Lee, Hon-Yi Lin, Shih-Kai Hung, Dian-Kun Li, Hsu-Chueh Ho, Moon-Sing Lee, Ya-Ting Tung, Pesus Chou, Yu-Chieh Su   +8 more
doaj   +1 more source

Postoperative serum amyloid A response after sutured scrotal castration without antimicrobial prophylaxis in 61 horses

Equine Veterinary Education, EarlyView.
Summary Background Serum amyloid A (SAA) is used clinically to monitor postoperative inflammation in horses, but reference information is limited after sutured scrotal castration performed without antimicrobial prophylaxis. Objectives To describe postoperative SAA concentrations and short‐term clinical outcome after sutured scrotal castration without ...
I. Sjöberg, K. Ljungvall, P. H. Andersen   +2 more
wiley   +1 more source

Haptoglobin phenotyping analysis by immunoblot.

, 2019
Haptoglobin proteins in serum samples of patients and controls were detected by anti-haptoglobin polyclonal antibodies and compared to protein standards to determine phenotype.
Mary Ajamian (422748), Gennaro Rosella (6204554), Peter R. Gibson (3145428), David Steer (2569642)   +3 more
core   +1 more source

SHIP1 regulates TREM2 signalling and macrophage functions in a hiPSC‐derived model

The FEBS Journal, EarlyView.
In this study, we characterised the role of SHIP1 in regulating TREM2 signalling and global microglial myeloid functions using human‐induced pluripotent stem cell (hiPSC)‐derived macrophages. Knockout of SHIP1 (SHIP1 KO) in macrophages decreased inflammatory activation and levels of scavenger receptors. SHIP1 KO macrophages also exhibited reduced TREM2
Kim S. Martin, Juliane Obst, Shania Ibarra, Emma J. Murphy, Katerina O. Gospodinova, Emma Mead   +5 more
wiley   +1 more source

Fucosylation Is a Promising Target for Cancer Diagnosis and Therapy

Biomolecules, 2012
Oligosaccharides, sequences of carbohydrates conjugated to proteins and lipids, are arguably the most abundant and structurally diverse class of molecules.
Shinichiro Shinzaki, Hitoshi Matsumoto, Tsutomu Nakagawa, Mika Terao, Cheng-Cheng Tan, Naoko Terao, Kenta Moriwaki, Eiji Miyoshi, Yoshihiro Kamada   +8 more
doaj   +1 more source

Serum Agalactosyl IgG Predicts Hepatocellular Carcinoma and All‐Cause Mortality After SVR in Advanced Chronic Hepatitis C

Hepatology Research, EarlyView.
ABSTRACT Background and Aims Patients with chronic hepatitis C and advanced fibrosis remain at substantial risk of hepatocellular carcinoma (HCC) and non‐liver–related death even after sustained virological response (SVR) to direct‐acting antivirals (DAA).
Daisuke Sakon, Jumpei Kondo, Yuki Tahata, Hayato Hikita, Maki Iwaisako, Muya Matsumoto, Asuka Ogata, Shinji Takamatsu, Yasutoshi Nozaki, Naruyasu Kakita, Hisashi Ishida, Fumihiko Nakanishi, Yuichi Yoshida, Masanori Nakahara, Kazuho Imanaka, Mitsuru Sakakibara, Takayuki Yakushijin, Tetsuo Takehara, Takahiro Kodama, Eiji Miyoshi   +19 more
wiley   +1 more source

Single‐centre analysis of severe Coombs‐positive autoimmune haemolytic anaemia in an HIV‐endemic population

HIV Medicine, EarlyView.
Abstract Introduction Human immunodeficiency virus (HIV) is a rare cause of autoimmune haemolytic anaemia (AIHA) which requires prompt diagnosis and treatment. We compared clinical and laboratory findings in AIHA patients with and without HIV. Methods We included adults with severe AIHA (haemoglobin ≤8 g/dL) diagnosed at a tertiary academic centre ...
Kathleen O. De John, Karryn Brown, Jenna Bailey, Estelle R. Verburgh, Jessica J. Opie   +4 more
wiley   +1 more source

AustrAIHANZ – consensus guidelines on the investigation and management of autoimmune haemolytic anaemia in Australia and New Zealand

Internal Medicine Journal, EarlyView.
Abstract Autoimmune haemolytic anaemia is a rare immune‐mediated disorder leading to accelerated red cell destruction and anaemia. There is considerable clinical heterogeneity, with some patients barely requiring intervention, while others experience fulminant haemolysis and experience mortality rates as high as 30% with severe anaemia and end‐organ ...
Philip Choi, Eileen Merriman, Ashwini Bennett, Anoop Enjeti, Chee Wee Tan, Isaac Goncalves, Danny Hsu, Jun Yen Ng, Anastazia Keegan, Robert Bird   +9 more
wiley   +1 more source

Haptoglobin is dispensable for haemoglobin uptake by Trypanosoma brucei

Frontiers in Immunology
Haptoglobin is a plasma protein of mammals that plays a crucial role in vascular homeostasis by binding free haemoglobin released from ruptured red blood cells.
Eva Horáková, Eva Horáková, Marek Vrbacký, Martina Tesařová, Eva Stříbrná, Jan Pilný, Zuzana Vavrušková, Marie Vancová, Marie Vancová, Roman Sobotka, Roman Sobotka, Julius Lukeš, Julius Lukeš, Jan Perner   +13 more
doaj   +1 more source