Results 91 to 100 of about 68,235 (259)
Advances in Civil EngineeringDeformation monitoring of ultra-high pylons in super-long-span cable-supported bridges faces considerable challenges due to structural complexity, stringent installation accuracy requirements, and susceptibility to environmental interference when using ...
Xinpeng You +4 more
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Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Journal of Engineering and Applied ScienceTo meet the demands for efficient and high-precision assembly construction of steel reinforcement components in concrete structures, and to address the limitations of steel reinforcement binding methods for concrete box girder structures, two innovative ...
Feng Zhang, Min Wang, Hehui Zheng
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Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Conversation with Rebekah Weatherspoon
Journal of Popular Romance Studies, 2022 Julie E. Moody-Freeman
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Two vaccines, one pandemic: Retrospective insights into Covishield and Covaxin effectiveness
Asian Journal of Medical SciencesBackground: Considering the emergence of new variants, it becomes essential to know the dynamics of the antibody profile for coronavirus disease 2019 (COVID-19) disease and its protective efficacy provided by the vaccines.
Indranil Thakur +3 more
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Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
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Molecular Oncology, EarlyView.The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant +7 more
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