Results 111 to 120 of about 123,840 (297)
Harnessing Marine Renewable Energy from Poole Harbour: Case Study
, 2012 Global warming and its impact on our environment, society, economies and security is one of the fundamental concerns of our time. In response, the United Kingdom government has put in place a legally binding target of an 80% reduction in greenhouse gas ...
Ball, F. +7 more
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
9.03.004: "Tickle Harbour: CBFF, 1984"
, 1984 Tickle Harbour at the ...
Tickle Harbour (Musical group)
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Hydrodynamic impacts of tectonics in prehistoric Ohiwa Harbour, North Island, New Zealand
, 2012 Ohiwa Harbour is an estuarine lagoon located in the eastern Bay of Plenty, North Island, New Zealand. Ohiwa Harbour is bounded by two sand spits, Ohope and Ohiwa Spits.
Robinson, Benjamin Joseph
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
2.04.010: 8 Colour snapshots: friends of Tickle Harbour, 1990s
, 1990 Photographs of several friends of Tickle ...
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, 2012 This study was funded by the Aarhus University Research Foundation, the Danish Ministry of Environment (Jagttegnsmidlerne) and by frame grants to PTM from the National Danish Science Research Council.
Erin Ashe +16 more
core +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
5.11.023: Tickle Harbour recordings, [1990s]
, 1990 Track sheets and notes for the Tickle Harbour recording The Brule Boys in ...
Walsh, Don
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