Results 101 to 110 of about 123,840 (297)

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Experimental study on the connection performance of single taper sleeve locking-type joint

Journal of Engineering and Applied Science
In the pursuit of cost reduction and enhanced construction efficiency in the mechanical connection of reinforcing bars within precast assembled concrete structures, a novel-reinforcing bar connection joint is introduced.
Dongdong Li, Tongheng Tu, Xiuli Yang, Maolin Cheng, Hao Xiao   +4 more
doaj   +1 more source

FAMAGUSTA HARBOUR, CYPRUS. [PDF]

Minutes of the Proceedings of the Institution of Civil Engineers, 1909
n ...
openaire   +2 more sources

Harbour Sushi

, 2016
Menu from Harbour Sushi restaurant in Port McNeill, BC. Meal combo specials, sushi combo specials, appetizers, soups & salads, noodle udon/soba, tempura, donburi rice bowl, teriyaki, sashimi, others (Korean style), bota sashimi/nigri, nigri sushi, combo ...
Harbour Sushi
core  

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Sliding characteristics of chute waste slag in high steep canyon ecologically sensitive areas

Scientific Reports
To address the significant ecological impact caused by constructing access roads for tunnel excavation in steep and rugged canyon areas, a novel method is proposed in this paper.
Peishuai Chen, Fuxiang Chen, Dejie Li, Jing Xiao, Juntao Zhu, Xutao Zeng, Shichao Zhang   +6 more
doaj   +1 more source

Harbour porpoises (Phocoena phocoena) and wind farms: a case study in the Dutch North Sea

, 2011
The rapid increase in development of offshore wind energy in European waters has raised concern for the possible environmental impacts of wind farms. We studied whether harbour porpoise occurrence has been affected by the presence of the Dutch offshore ...
Scheidat, M., Teilmann, J., Brasseur, S.M.J.M., Reijnders, P.J.H., Carstensen, J., van Polanen Petel, T., Polanen Petel, T., van, Tougaard, J.   +7 more
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Estimating the impact of bycatch and calculating bycatch limits to achieve conservation objectives as applied to harbour porpoise in the North Sea

, 2009
Incidental catch, or bycatch, of harbour porpoise (Phocoena phocoena) in fishing operations is an international conservation issue. The main objective of this thesis was to develop methods for determining the impact of bycatch on the state and dynamics ...
Winship, Arliss
core  

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source