Results 121 to 130 of about 123,840 (297)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Experimental study on mechanical properties of toothed blocks in concrete box girders with new prefabricated reinforcement parts

Journal of Engineering and Applied Science
To meet the demands for efficient and high-precision assembly construction of steel reinforcement components in concrete structures, and to address the limitations of steel reinforcement binding methods for concrete box girder structures, two innovative ...
Feng Zhang, Min Wang, Hehui Zheng
doaj   +1 more source

THE SANITATION OF MARSEILLES HARBOURS.

The Lancet, 1884
n ...
openaire   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Two vaccines, one pandemic: Retrospective insights into Covishield and Covaxin effectiveness

Asian Journal of Medical Sciences
Background: Considering the emergence of new variants, it becomes essential to know the dynamics of the antibody profile for coronavirus disease 2019 (COVID-19) disease and its protective efficacy provided by the vaccines.
Indranil Thakur , Pradip Kumar Chowdhury , Ashis Kumar Ghosh , Debalina Mukherjee   +3 more
doaj   +1 more source

Report on proposed improvements to Teignmouth Harbour

, 1971
This is the Report on Proposed Improvements to Teignmouth Harbour from 15th March, 1971 prepared for the Teignmouth Harbour Commission.It reviews the Scheme III Breakwater along the lines recommended by the Hydraulics Research Station and the ...

core  

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Conversation with Rebekah Weatherspoon

Journal of Popular Romance Studies, 2022
Julie E. Moody-Freeman
doaj  

2.12.013 Tickle Harbour Webcast, 1999

, 1999
CFog.net was a company that did live webcasts. This is one they did with Tickle Harbour. on stage are Patrick Boyle, Allison Neary, Fergus O'Byrne, Francesca Swann, Vonnie Barron, Gerry Strong, Angela Pickett, and Don ...
Tickle Harbour (Musical group)
core  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source