Results 131 to 140 of about 123,840 (297)

Birds eye view of the Port of Sydney /

, 1919
Birds-eye view of Port Jackson with relief shown pictorially and by landform drawing. Depths shown by bathymetric soundings.; National Library of Australia's copy shelved at MAP G8974.S9P55 1919, not folded in cover. ANL; In: The Port of Sydney, N.S.W. :
Sydney Harbour Trust, cartographer.
core  

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

711 HBM1022, a novel anti-CCR8 antibody depletes tumor-infiltrating regulatory T cells via enhanced ADCC activity, mediates potent anti-tumor activity with Keytruda

Journal for ImmunoTherapy of Cancer, 2020
Yun He, Juan Liu, Fei Chen, Yang Cao, Yuntao Wu, Lei Niu, Shuang Lu, Shaoping Hu, Xin Gan, Yongqiang Wang, Chuchu Zhao, Yi Ding, Jinqiu He, Qing Du, Xiaocheng Lv, Beibei Qin, Yuandong Wang, Yunxing Yang, Musheng Bao, Jason Noon, Wenhao Yu, Joe Zhao, Yiping Rong   +22 more
doaj   +1 more source

Birds eye view of general wharfage scheme west of Dawes Point as it will appear when completed [cartographic material] /

, 1912
Birds eye view of wharves between Dawes Point and Rozelle Bay, N.S.W.; In: The Port of Sydney, N.S.W. : official handbook. Sydney : Published by the Sydney Harbour Trust Commissioners, 1913.; Also available in an electronic version via the Internet at ...
Sydney Harbour Trust.
core  

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Harbour and Maritime Simulation [PDF]

SIMULATION, 1998
openaire   +1 more source

Are toxins from harmful algae a factor involved in the decline of harbour seal populations in Scotland?

, 2015
Firstly this study builds on the investigation initiated by Hall and Frame (2010), which found that Scottish harbour seals were exposed to domoic acid (DA), a potent natural neurotoxin produced by phytoplankton.
Jensen, Silje-Kristin
core  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source