Results 101 to 110 of about 956,014 (301)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Synchronization of oscillators with hard excitation coupled with delay Part 2. Amplitude-phase approximation [PDF]

open access: yesИзвестия высших учебных заведений: Прикладная нелинейная динамика
Aim of this work is to develop the theory of mutual synchronization of two oscillators with hard excitation associated with a delay. Taking into account the delay of a coupling signal is necessary, in particular, when analyzing synchronization at ...
Adilova, Asel Bauyrzhanovna   +1 more
doaj   +1 more source

Collective Modes in a Slab of Interacting Nuclear Matter: The effects of finite range interactions

open access: yes, 1993
We consider a slab of nuclear matter and investigate the collective excitations, which develop in the response function of the system. We introduce a finite-range realistic interaction among the nucleons, which reproduces the full G-matrix by a linear ...
A. De Pace   +17 more
core   +1 more source

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

open access: yesFEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli   +9 more
wiley   +1 more source

Experimental Determination of Amplitude-Frequency Characteristics in Response to Sound Strengthening of Hard Alloys

open access: yesНаука и техника, 2019
The paper proposes to reach such external energy which is sufficient for shifting carbide atoms and binding through application of resonance effect on frequencies that corresponds to sound wave spectrum.
V. K. Sheleg, A. N. Jigalov
doaj   +1 more source

Zero-Energy Modes from Coalescing Andreev States in a Two-Dimensional Semiconductor-Superconductor Hybrid Platform

open access: yes, 2017
We investigate zero-bias conductance peaks that arise from coalescing subgap Andreev states, consistent with emerging Majorana zero modes, in hybrid semiconductor-superconductor wires defined in a two-dimensional InAs/Al heterostructure using top-down ...
Hamilton, Alexander R.   +6 more
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Spin waves in the soft layer of exchange-coupled soft/hard bilayers

open access: yesAIP Advances, 2016
The magnetic dynamical properties of the soft layer in exchange-coupled soft/hard bilayers have been investigated numerically using a one-dimensional atomic chain model.
Zheng-min Xiong   +9 more
doaj   +1 more source

Stability of Nonlinear Normal Modes in the FPU-$\beta$ Chain in the Thermodynamic Limit

open access: yes, 2011
All possible symmetry-determined nonlinear normal modes (also called by simple periodic orbits, one-mode solutions etc.) in both hard and soft Fermi-Pasta-Ulam-$\beta$ chains are discussed.
D. S. Ryabov   +10 more
core   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

open access: yesFEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies   +3 more
wiley   +1 more source

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