Results 41 to 50 of about 52,895 (259)
Evaluation of Laser Structuring in Hard Turning Process of Martensitic Steel
Journal of Manufacturing and Materials ProcessingThe hard turning process presents significant challenges compared to conventional turning techniques, particularly in terms of controlling machining forces and dimensional accuracy. This study evaluates the effectiveness of laser structuring in enhancing
Esmaeil Ghadiri Zahrani +3 more
doaj +1 more source
Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
Comparing the paths of Hedgehog release in artificial and natural settings
FEBS Letters, EarlyView.Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
International Journal of Mechanical and Materials Engineering, 2019 In the machining operations, final surface finish and dimensional accuracy are the most specified customer requirements. Hard turning machining operation using cubic boron nitride tool as an alternative of grinding process is a type of turning operation ...
Sasan Yousefi, Mehdi Zohoor
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Hard Turning of Bearing Raceway
, 2008 Application of ceramic inserts in machining of large diameter ball bearing raceway surface, previously hardened (2 mm in depth on 56 +3 HRc), fulfils our expectances in bearing ring productivity increase. This finishing procedure is satisfactory in achieving demanded raceway quality and ensure machining time reduction. Quality is achieved even the hard
Samardžić, Ivan, Stoić, Antun
openaire +3 more sources
Литьë и металлургия, 2018 The successful promotion of the product nowadays the manufacturer must meet all the strict requirements of the consumer in the quality of the products. At OJSC «BSW – Management Company of Holding «BMC» the centerless turning unit was put into operation,
O. Filonchik
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source