Results 61 to 70 of about 55,629 (302)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Potentials and applications of fine hard turning - An overview

, 2023
491493Das Hartdrehen bietet für viele Anwendungen eine interessante Alternative zum Schleifen. Verfahrensspezifische Vorteile wie kurze Rüstzeiten, die Möglichkeit zur Trockenbearbeitung und eine hohe Flexibilität machen Hartdrehprozesse sowohl for die ...
Klocke, Fritz, Jochmann, Sven
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Research of Roughness of Hard Turning Bores

, 2010
This paper reports an extensive characterization of the surface roughness generated during hard turning operations performed with conventional PCBN tools and during combination turning and grinding machining.
Szakács, Katalin
core   +1 more source

Statistical Analysis of the effect of cutting parameters on the surface roughness profile height parameter Ra in hard turning of steel C(55) DIN [PDF]

, 2020
The study investigates the surface height roughness parameter Ra (roughness arithmetic average) as a technological effect on the quality of the of the steel C 55 (DIN) surface in hard turning; the variation of the input process parameters cutting speed ...
Pira, Bujar, Shabani, Mevludin, Simeonov, Simeon, Ostergllava, Naim   +3 more
core  

Evaluation of Laser Structuring in Hard Turning Process of Martensitic Steel

Journal of Manufacturing and Materials Processing
The hard turning process presents significant challenges compared to conventional turning techniques, particularly in terms of controlling machining forces and dimensional accuracy. This study evaluates the effectiveness of laser structuring in enhancing
Esmaeil Ghadiri Zahrani, Amir Alinaghizadeh, Amirmohammad Fakharzadeh Jahromi, Bahman Azarhoushang   +3 more
doaj   +1 more source

MQL-Assisted Hard Turning of AISI D2 Steel with Corn Oil: Analysis of Surface Roughness, Tool Wear, and Manufacturing Costs

Metals, 2021
Precision hard turning (HT) gained more and more attention in the cutting industry in the last years due to continuous pressure of the global market for reducing costs, minimizing the environmental and health issues, and achieving a cleaner production ...
Bogdan Arsene, Catalin Gheorghe, Flavius Aurelian Sarbu, Magdalena Barbu, Lucian-Ionel Cioca, Gavrila Calefariu   +5 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source