Results 51 to 60 of about 1,078,718 (347)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Investigative Analysis On Hard Turning Process

International Journal of Scientific Research in Science and Technology, 2019
In the present work, the work piece material taken is chrome-moly alloy steel. This is a hard material having hardness 48 HRC. This alloy steel bears high temperature and high pressure and its tensile strength is high. It is very resistive to corrosion and temperature.
Gaddam Vasikerappa, G. Rajkumar, C. Mohan Naidu   +2 more
openaire   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Cutting forces in interrupted hard turning

, 2018
The paper presents the parameters that determine the variability of the cutting conditions in the turning process. The experimental results are given for the measurement of the cutting forces during turning of steel Č 1530. The experiment was done on the TNP 160 Prvomajska turning machine using insert CNMG 120408 HA.
Smojvir, Denis, Duspara, Miroslav, Stoić Katarina, Stoić, Antun, Stoić, Marija   +4 more
openaire   +3 more sources

Evaluation of Laser Structuring in Hard Turning Process of Martensitic Steel

Journal of Manufacturing and Materials Processing
The hard turning process presents significant challenges compared to conventional turning techniques, particularly in terms of controlling machining forces and dimensional accuracy. This study evaluates the effectiveness of laser structuring in enhancing
Esmaeil Ghadiri Zahrani, Amir Alinaghizadeh, Amirmohammad Fakharzadeh Jahromi, Bahman Azarhoushang   +3 more
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

The efficiency of combined machinings [PDF]

, 2012
This paper analyses the efficiency of the finish process applied in machining of hard surfaces, completed by grinding, hard turning and also by the combination of these two procedures, on the basis of time ...
Deszpoth, I., Gyáni, K., Kundrák, J.
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Rationalization of Sintered Carbide Valve Machining for Wire Rolling [PDF]

, 2017
Předkládaná diplomová práce se zabývá problematikou obrábění těžkoobrobitelných tvrdých materiálů, konkrétně slinutého karbidu technologií soustružením. V teoretické části jsou shrnuty základní údaje o tvrdých materiálech jejich mechanických vlastnostech,
Verlík, Jan
core